Release form


Pharmachologic effect


Pharmacodynamics and pharmacokinetics


Trimethine Derivative oxazolidinedione. It has an anticonvulsant effect, as well as an analgesic effect for neuralgic pains. In small doses, it prevents central arousal. Reduces focal activity and enhances inhibition in the spinal cord, while not affecting the transmission of impulses in the brain. With small epileptic seizures, the frequency of peak-wave complexes decreases. The active metabolite blocks calcium channels in the hypothalamic neurons. Used in conjunction with barbiturates. The therapeutic effect is manifested after 2-3 weeks. With prolonged use, it accumulates in the body.


It is well absorbed in the digestive tract, evenly distributed. Demethylation is destroyed in the liver and excreted by the kidneys as a metabolite.

Indications for use

As part of complex therapy, Trimethine is used for:

  • small forms epilepsy;
  • akinetic forms epilepsy;
  • mental agitation.


  • hypersensitivity;
  • pathology of the optic nerve;
  • diseases of the blood-forming organs;
  • impaired liver / kidney function;
  • pregnancy.

Side effects

Trimethine may cause the following adverse events:

  • skin rashes;
  • dizziness;
  • photophobia;
  • confusion;
  • swelling of the optic papilla;
  • mydriasis;
  • scotoma;
  • hemeralopia (visual disturbance in the dark);
  • difficulty swallowing and breathing;
  • stomach ache;
  • hepatitis;
  • hair loss;
  • neutropenia;
  • agranulocytosis;
  • anemia;
  • eosinophilia.

Trimethine, instructions for use (Method and dosage)

Inside, with food, 0.25 g twice a day, for children 0.05-0.2 g (depending on age) 2 times a day. Assign in the morning and afternoon to prevent attacks at night. Very rarely, a small dose is taken at bedtime. The highest dose is a single 0.4 g, and a daily dose of 1.2 g.

Treatment for small forms epilepsy conducted by courses up to 5 months along with barbiturates (Sereysky mixture) Upon achieving stable remission, the dose is gradually reduced and the drug is canceled. In the future, only barbiturates are prescribed. Therapeutic effect in the treatment epilepsy unstable, there are relapses.

At neuralgia treatment lasts 1-2 months.

During the treatment period, a blood test is conducted every week. Even with serious complications, treatment should not be abruptly canceled to avoid deterioration. It is recommended to reduce the daily dose and gradually cancel.

There is a veterinary drug with the same name, but with a different active substance (sulfamethoxazole and trimethoprim) and for other indications (bacterial infections). These are diseases of the urinary tract, respiratory tract, salmonellosis and colibacillosis. The drug is produced in tablets of 0.68 g and in powder.

Instructions for use Trimethine for animals

Animals are administered orally at 0.68 g per 15 kg of weight twice a day, from 6 to 10 (with salmonellosis) days.


Overdose manifests itself drowsiness, which can be replaced by excitability, also appear dizzinessviolation of coordination of movements and hallucinations.


Enhances the inhibitory effect on the central nervous system with the use of similar agents and ethanol. Development myasthenia gravis It is noted when used with anticholinesterase drugs. When applying acetazolamide intensifies the toxic effect on the optic nerve.

Terms of sale

Released by prescription.

Storage conditions

Storage temperature up to 20 ° ะก.

Shelf life

5 years.


Trimethadione, Tridion, Trimedat, Ptimal, Absentol, Epidion, Edion, Ruffled, Petidion, Troxidone.


Trimethine has been known since 1946 and is currently not used, due to its low effectiveness, significant toxicity, high teratogenicity, as well as the emergence of more effective drugs, including retard forms. In addition, as monotherapy it is impractical to use.

It was previously prescribed in combination with barbiturates (Sereysky mixture) Treatment began with phenobarbital, then this drug was added, and then - diacarb. This scheme allowed to significantly reduce the dose. trimethine and the severity of side effects. There was an opportunity to carry out treatment up to a year. With this combination treatment, the attacks disappeared completely or were much less common.

In the treatment with this agent more often than with the appointment of other anticonvulsants, skin lesions occur: erythematous and bullous dermatitis, acne-like rashes. Blood changes are very dangerous - agranulocytosis, anemia, monocytosis, leuko and thrombocytopenia. Are also developing hepatitis and kidney damage. However, even if such serious complications appeared, treatment cannot be immediately canceled, since an epileptic status may develop.

Price, where to buy

It is currently impossible to purchase the drug Trimethine in the pharmacy chain due to the expiration of its registration in 2002.

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