In 1 ml solution - meldonium dihydrate 100 mg

IN 1 capsule - meldonia 250 mg or 500 mg. Magnesium stearate, potato starch, silicon dioxide - as excipients.

Release form

  • capsules 500 mg and 250 mg;
  • injection.

Pharmachologic effect

Anti-ischemic, cardioprotective (improves myocardial metabolism and energy supply).

Pharmacodynamics and pharmacokinetics


It has a cardioprotective effect, in addition to membrane-stabilizing and immunotropic. Limits the rate of synthesis carnitine of γ-butyrobetainethat entails a violation of the transport of fatty acids in mitochondria. Under the influence of the drug, the level rises γ-butyrobetainewhich enhances education nitric oxidethat leads to a decrease OPSS and vasodilation.

Meldonium reduces ability platelet count aggregation and improves membrane elasticity red blood cells. In conditions of ischemia prevents the violation of transport ATP. With ischemic damage to the heart muscle, it slows down the formation of a necrosis zone. With heart failure increases myocardial contractility and reduces the number of seizures angina pectoris. Effective in the pathology of the vessels of the fundus. Increases efficiency. Eliminates nervous system disorders in patients with chronic alcoholism.


It is well absorbed when taken orally. The bioavailability with this method of administration is 78% and 100% when administered intravenously. Cmax is determined in the blood after 1-2 hours. It is metabolized with the formation of two metabolites, they are excreted by the kidneys unchanged.

Indications for use

Complex therapy:

  • Ischemic heart disease;
  • reduced performance;
  • dishormonal cardiomyopathies;
  • postoperative rehabilitation;
  • cerebrovascular accident;
  • physical overvoltage;
  • withdrawal syndrome in chronic alcoholism.

Parabulbar administration:

  • retinal hemorrhage;
  • circulatory disorders in the retina;
  • retinal vein thrombosis;
  • retinopathies (diabetic and hypertonic).


  • Increased intracranial pressure;
  • pregnancy;
  • lactation;
  • hypersensitivity;
  • under the age of 18 (capsules).

Side effects

All adverse reactions are rare:

  • psychomotor agitation;
  • tachycardia;
  • dyspeptic disorders;
  • changes HELL (decrease or increase);
  • itchy skin;
  • rash.

Meldonium, instructions for use (Method and dosage)

Capsules Meldonium-MIK taken orally and in connection with the possibility of an exciting effect, it is recommended to take them in the morning. The dose and frequency of administration are selected individually.

With cardiological diseases - 500 mg-1000 mg per day. Treatment lasts up to 6 weeks.

In cases of cerebrovascular accident - 500 mg once a day, in a course of 4-6 weeks.

At withdrawal syndrome - 500 mg 4 times a day.

With physical overload - 250 mg 4 times a day, course of 14 days.


Usually the dose is 0.5-1 g per day daily. The drug is administered per 10 ml of 0.9% solution NaCl.

Unstable angina pectoriscondition after suffering myocardial infarction - injected in / in a jet of 1-2 ampoules (500-1000 mg) 1 time per day for 4 days in a row. Stable angina pectoris: dosage and frequency of administration are the same.

Parabulbally injected with 0.5 ml of solution.


The drug is slightly toxic and overdose cases do not occur or are extremely rare. Development is theoretically possible hypotension, tachycardia, headache, dizziness and general weakness. Symptomatic treatment is carried out.


Enhances the action of antihypertensive, antianginal drugs, cardiac glycosides.

Perhaps a combination with antianginal drugs, anticoagulants, antiarrhythmic drugs and diuretics.

With simultaneous use with Nitroglycerin, alpha adrenergic blockers, Nifedipineperipheral vasodilators are likely tachycardia and arterial hypotension.

Do not use simultaneously with other drugs containing meldonium.

Terms of sale

It is released on prescription.

Storage conditions

Storage temperature up to 25 ° C.

Shelf life

2 years.

Analogs of Meldonium

Matches for ATX Level 4 code:FlowerpotPhosphadenHawthorn fruitPreductalCytochrome CAngiosil RetardRaneksaLily of the valley tinctureNeocardylNeoton Whitening SerumRimecorTriductanATF LongHawthorn tinctureTriductan MVTrimectal MVTrimectalNeotonPredizinTrimetazidine

Mildronate, Idrinol, Midolate, Flowerpot, Vazomag.

Reviews about Meldonia

The appointment of this drug in the complex treatment of cardiac pathology reduces by 55.6% the number of seizures angina pectoris and daily requirement for nitroglycerin by 55.1%. Significantly improves contractions myocardium no effect on heart rate, limits fluctuations HELL. The drug is low toxic and does not cause severe adverse reactions.

Judging by the reviews of patients, this remedy was prescribed for Ischemic heart disease in combination with antianginal and antihypertensive drugs. It is important that the drug was prescribed to patients of older age groups and they tolerated it well.

  • ".... I was added Meldonium tablets for angina pectoris, to other tablets. Noticed improvement after 3 weeks";
  • "... I took 2 times a day after a micro stroke in capsules. Drank a month and a half - speech improved, vigor appeared";
  • "... I take courses three times a year. I can characterize it as vital for everyone. I have angina pectoris and a slightly increased blood pressure";
  • "... The child is one year old, very tired. On the recommendation of a neurologist, I take Meldonium twice a day. I drink only a week and already feel better";
  • "... I was recommended by a neurologist (diagnosis of "chronic fatigue"). Pricked injections. Excellent drug, quickly returns strength";
  • "... I noticed that taking Meldonium slightly increases the appetite, even recovered a little";
  • "... After 7 days of taking this drug, my head became dizzy".

The price of Meldonium, where to buy

You can buy the drug at any pharmacy. More often, a drug in the form of injections is offered, the cost of which ranges from 135-169 rubles. for 10 ampoules.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine


  • Meldonium caps. 250mg No. 40 Biochemist PAO158 rub.order
  • Meldonium - binergy solution d / in. 100mg / ml 5ml No. 10FKP Armavir Biological Factory227 rub.order
  • Meldonium-solopharm solution d / in. 100 mg / ml amp. 5ml №10OOO "Groteks" 230 rub.order
  • Meldonium organic caps. 250mg No. 40AO Organika 175 rub.order
  • Meldonium organic caps. 500mg No. 60AO Organika499 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Meldonium-solopharm injection 10% 5 ml 10 ampGroteks OOO120 rub.order
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Pani Pharmacy

  • MELDONIUM ampoule Meldonium solution d / in. 100 mg / ml 5ml amp. No. 10 Ukraine, Yuriya-Farm OOO 341 UAH.order
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Watch the video: What is meldonium? (February 2020).

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