The structure of Quentiax includes an active component: quetiapine fumarate.
Additional components: lactose monohydrate, povidone, calcium hydrogen phosphate dihydrate, sodium carboxymethyl starch, magnesium stearate, hypromellose, titanium dioxide, macrogol, iron dye.
Quentiax is available in tablets, which are film-coated and contain 100 mg, 200 mg and 300 mg of the active substance. Tablets are packaged in 10 pieces in blisters, 6 blisters per pack.
Characteristic for the drug antipsychoticact.
Pharmacodynamics and pharmacokinetics
Quentiax tablets are atypical antipsychotic drugs similar to receptors serotonin. Also, the drug exhibits an affinity for histamine and alpha-1 receptors and a little with alpha-2 receptors.
The use of these tablets in the prescribed dosage does not cause extrapyramidal symptoms, does not lead to a prolonged increase in the concentration of prolactin in the composition blood plasma.
The positive therapeutic effect, noted from the very beginning of taking the tablets, is maintained for a long time. Their effect on serotonin and dopamine receptors is more than 12 hours.
This drug is characterized by high absorption, while its bioavailability is independent of food intake. Plasma protein binding reaches about 83%. In the body, the drug undergoes active metabolism in the liver. As a result, pharmacologically inactive metabolites. The drug is excreted in several stages in metabolites and unchanged with the help of the kidneys and intestines.
Indications for use
The drug is indicated for use in the treatment of:
- acute and chronic forms psychosis, including schizophrenia;
- manic episodespeculiar to bipolar disorder.
Quentiax tablets are not prescribed for:
- sensitivity to their components;
- patients under the age of 18 years.
In addition, caution is necessary in the treatment of patients suffering from cardiovascular and cerebrovascular disorders and other conditions accompanied by arterial hypotension, congenital increase in the QT interval on the ECG, the elderly, liver failure, epilepsy and with pregnancy.
During treatment with Quentiax, side effects may occur that affect the work of the nervous, respiratory, lymphatic and cardiovascular systems, blood-forming organs, gastrointestinal tract, and so on.
Therefore, the development of adverse symptoms is possible, such as: leukopenia, eosinophilia metabolic disorder leading to weight gain, dizziness, headache, drowsiness, syncopal conditions, tachycardiaarterial hypotension, rhinitispharyngitis, dry mouth, diarrhea, constipation, dyspepsia, allergic reactions, swelling, asthenia and so on.
Quentiax, instructions for use (Method and dosage)
These tablets are intended for oral administration, for a 2-time intake per day. In this case, the dosage is selected depending on the type of violation and is often prescribed for use according to a certain scheme.
For example, during treatment of an acute or chronic form of psychosis, including schizophrenia, the daily dosage for the first 4 days is usually: on the 1st day - 50 mg, on the 2nd day and 3rd take Quentiax 200 mg tablets, and on the 4th day the dose is increased to 300 mg. In the future, the drug is taken in this daily dosage, although it is possible to lower or increase it in the range of 150-750 mg.
During the treatment of manic episodes characteristic of bipolar disorders, this drug can be prescribed as mono- or adjuvant therapy to stabilize mood. The dosage is prescribed by the attending physician, suggesting its gradual increase, but not more than 800 mg per day.
Cases of overdose with this agent are quite rare. This usually happens when it is significantly exceeded. As a rule, undesirable symptoms disappear after lowering the dosage on their own.
However, in patients suffering from severe cardiovascular disorders, the risk of side effects with an overdose increases.
In this case, the main symptoms of an overdose are: tachycardia, severe sedation, drowsinesslowering blood pressure.
In such situations, patients are prescribed symptomatic treatment and other measures to help support respiratory and cardiovascular functions.
Specific antidotes not developed.
When taking quetiapine, there is no induction of liver enzyme systems involved in metabolism Phenazone and lithium.
Combination with drugs capable of inhibiting hepatic enzymes, eg, Carbamazepine or Phenytoinas well as Rifampicin and barbituratesmay lower plasma concentrations of quetiapine.
Concomitant use of quetiapine with CYP3A4 inhibitors (antifungal agents of the azole group and macrolide antibiotics) often increase plasma concentrations of the drug. This is especially necessary to consider when treating debilitated patients and in old age.
Various drugs that can inhibit the functioning of the nervous system can increase the risk of adverse effects.
The purpose of the drug, as well as its abolition, requires the use of a special scheme - increasing or decreasing, with subsequent cancellation, gradually. Otherwise, the development of the "withdrawal syndrome", accompanied by nausea, vomiting, insomnia, exacerbation of psychotic symptoms and so on.
When used with drugs that extend the QT interval, maximum caution should also be exercised, especially in the treatment of elderly people, with hypokalemia, congestive heart failure, hypomagnesemia.
No less attention is required when combining this drug with other drugs. As a rule, to reduce or completely eliminate the manifestation of various undesirable effects allows lower dosage.
It was established that the effect of the drug on concentration and the speed of psychomotor reactions is possible. Therefore, people whose work is related to driving and other potentially dangerous activities need to be extremely careful.
Terms of sale
For storage of tablets, a place with a temperature of up to 30 ° C, inaccessible to children, is suitable.
Quentiax AnalogsMatches for ATX Level 4 code:LaquelLeponexZalastaClozastenKetileptZiprexOlanzapineClozapineQuetiapineSeroquelAzaleptin
The main analogues of Quentiax: Ketilept, Quetiapine and Seroquel.
Alcohol and Quentiax
It is known that ethanol able to increase the risk of developing negative symptoms. Therefore, it is better to refrain from drinking alcohol.
Numerous reviews of Quentiax are found on medical forums, the topics of which are associated with various mental disorders. Especially often, this drug is prescribed to patients suffering from panic attacks. According to users, the effectiveness of treatment is manifested in almost all cases. As a result, fears completely recede, but for many patients drowsiness accompanies throughout the treatment, which can be very undesirable.
An important condition for effective treatment is that only specialists should prescribe this drug. The fact is, the therapeutic regimen, and especially its dosage, requires a certain approach, with a gradual increase, and then a decrease in dose. Upon reaching the therapeutic effect, it is possible to prescribe a maintenance dose of Quentiax 100mg. Usually this is enough to consolidate the therapeutic effect.
You can also find reports of the development of undesirable effects manifested by extrapyramidal disorders, increased appetite, weight gain and headaches. One way or another, compared with other analogues, the use of this medication is accompanied by fewer side effects.
Experts say that taking this drug without a prescription is not recommended. Although, as the reviews show, none of the patients started taking it on their own. Moreover, often these pills are prescribed during inpatient treatment. In any case, doctors warn patients against taking this medicine on their own, as well as deviations from the therapeutic regimen. This can lead to a violation of the internal regulation of the body, as well as to an even greater aggravation of the state of the psyche.
Quentiax price where to buy
The price of Quentiax in tablets varies between 1700-4200 rubles. You can buy Quentiax in almost any Russian pharmacy with a prescription.
- Online Pharmacies in Russia
- Quentiax Tab. n / a captive. 300mg No. 60Krka-Rus LLC2755 rub.order
- Quentiax Tab. p.p.o. 200mg n60Krka-Rus OOO2101 rub.order
- Quentiax Tab. n / a captive. 25 mg No. 60Krka-Rus OOO468 rub.order
- Quentiax tablets 100mg №601210 rub.order
- Quentiaks (tab.pl./200.200mg No. 60) 2276 rub.order