Medication

Clindacin

Structure

1 dose (5 grams) cream includes 100 mg of phosphate clindamycin. Additionally: 1/2 propylene glycol, sodium benzoate, castor oil, polyethylene oxide, emulsifier.

1 candle (suppository) includes 100 mg of phosphate clindamycin. Additionally: semi-synthetic glycerides (according to the type "Suppotsir", "Vitepsol", "Estarinum").

Release form

The drug Clindacin is made in the form of a vaginal cream in aluminum tubes of 20 grams (with 3 applicators in the kit) or 40 grams (with 7 applicators in the kit), as well as in the form of suppositories of 3 pieces in a pack.

Pharmachologic effect

Local antibacterial (broad spectrum).

Pharmacodynamics and pharmacokinetics

Clindacin, including as an active ingredient lincosamide antibiotic - clindamycinis a local remedy used in gynecology for the treatment of gardnerellosis (vaginosis) of bacterial origin. The mechanism of action of local dosage forms of the drug (cream, suppositories) is aimed at disrupting the processes of intracellular protein synthesis in the microbial cell, which occurs at the level of the large 50S ribosomal subunit.

Action spectrum clindamycin wide enough. In medium doses, the bacteriostatic effectiveness of the drug in relation to many microorganisms. In higher dosages clindamycin characterized by bactericidal action aimed at the destruction of some bacterial strains.

Main activity clindamycin observed in relation to microorganismsleading to the formation bacterial vaginosisincluding: Mobiluncus spp. (mobilunkus) Gardnerella vaginalis (gardnerella vaginalis) Bacteroides spp. (bacteroids) Peptostreptococcus spp. (peptostreptococcus) Mycoplasma hominis (mycoplasma hominis).

Insensitive to exposure clindamycin are strains Candida albicans (thrush) and Trichomonas vaginalis (vaginal trichomonas).

Intravaginal (inside the vagina) a single injection of clindamycin at a dose of 100 mg leads to systemic absorption of about 4% of the drug (about 4 mg). The plasma Cmax of clindamycin is 20 ng / ml.

Indications for use

Clindacin cream and suppositories are indicated for local treatment bacterial vaginosisthat have developed as a result of exposure to clindamycin-sensitive microorganisms.

Contraindications

Both dosage forms of clindacin are contraindicated in women who are on I trimester of pregnancyas well as patients with personal hypersensitivity to clindamycin or lincomycin.

Side effects

Some patients with the use of clindacin felt the development of negative side effects, including: itching in the vaginaeducation maculopapular rashoccurrence urticariadevelopment cervicitis or colpita (vaginitis) vulvovaginal irritationfeeling burning.

From the hematopoietic system in rare cases, the following was observed: thrombocytopeniareversible leukopenia, eosinophilia, neutropenia, agranulocytosis.

In the case of significant systemic absorption of clindamycin, a manifestation of its inherent systemic side effects is possible, including the formation of pseudomembranous enterocolitis (rarely).

Instructions for use of clindacin (method and dosage)

Clindacin cream, instructions for use

Clindacin cream is intended for intravaginal use using a special, one-time applicator included in the kit for the medicinal product. The recommended single daily dosage of the cream is 100 mg clindamycin (volume of the fully filled applicator). The introduction of the drug is best done in the evening (before bedtime). The duration of the treatment course, as a rule, takes from 3 to 7 days.

Use of applicator

For proper dosing and administration of the cream into the vagina, it is recommended to use disposable applicators that are in the package with the drug and adhere to the technique of their use, namely:

  • remove the protective cap from the tube of cream;
  • screw in its place a disposable plastic applicator;
  • squeeze the opposite end of the tube to completely fill the applicator (the applicator is considered fully filled when its independently moving piston reaches the stop);
  • lying on your back, insert the applicator into the vagina as deep as possible;
  • gently push the applicator onto the piston until it is completely empty;
  • carefully remove the used applicator from the vagina and discard it.

Candles clindacin, instructions for use

Clindacin suppositories are also used intravaginally, with a single daily administration of the 1st suppository, preferably in the evening (before bedtime). The duration of the treatment course, as a rule, takes from 3 to 7 days.

For proper use of the drug, one suppository should be freed from the outer contour packaging by cutting the protective film along the contours of the candle. Then, in the supine position, enter the suppository into the vagina as deep as possible.

Overdose

Due to the low absorption of clindamycin due to its intravaginal use, the likelihood of an overdose is extremely small.

Interaction

When combined with clindamycin, the effectiveness of aminoglycosides is enhanced (Streptomycin), Rifampicin and Gentamicin.

Clindamycin is incompatible with Aminophylline, Erythromycin, Magnesium sulfate, Ampicillin, Calcium gluconatederivatives diphenylhydantoin and barbiturates.

The effects of clindamycin increase muscle relaxation due to exposure n-anticholinergics.

Terms of sale

The purchase of a cream requires a prescription, candles can be bought on the open market.

Storage conditions

Clindacin cream should be stored at an ambient temperature of up to 20 ° C, suppositories are stored in a temperature range of 15-25 ° C.

Shelf life

Both dosage forms of the drug will retain their healing qualities for 3 years.

Special instructions

In the case of prolonged use of the drug, the possibility of excessive growth of microorganisms insensitive to its active ingredient, in particular fungal strains, is allowed Candida.

The combined use of clindacin with other intravaginal therapeutic agents is not recommended.

Due to, albeit minimal, but still systemic absorption clindamycin (about 4%), against the background of its local application, the occurrence of diarrhearequiring withdrawal of the drug.

Analogs

Matches for ATX Level 4 code:EcofucinPrimafunginPolygynax VirgoPolygynax

Clindacin analogs are represented by local therapeutic drugs used by gynecologists for the treatment of such bacterial infections: Nystatin, Polygynax, Syntomycin, Pimafucin, Natamycin, Ecofucin.

The price of the analogs of the suppositories of this drug varies widely, for example 10 suppositories of the drug Syntomycin can be bought for 40-60 rubles, and 12 vaginal capsules Polygynax already for 600-650 rubles.

Synonyms

Local preparations with a similar active ingredient are: Clindamycin, Dalacin and Clines.

For children

Safety and efficacy profiles of clindacin in pediatric practice have not been established.

During pregnancy and lactation

According to official instructions, clinical studies of safety of clindacin when pregnancy in the first trimester was not carried out, in connection with which, its use in this period is not recommended. Clindacin treatment for women during II and III trimester of pregnancy allowed only in cases of significant excess of the benefits of such therapy for the mother, in comparison with the possible negative consequences for the fetus.

Despite this, in gynecology there is a practice of appointing clindacin in II and III trimester of pregnancysince some vaginal infectionscertainly need such treatment. Considering the reviews about this drug in the form of a cream, as well as the reviews about suppositories during pregnancy during these periods, it is worth noting that in the vast majority of cases, therapy with Clindacin led to the elimination of an infectious disease without any negative consequences for the expectant mother and fetus.

Isolation of Intravaginally Used clindamycin with milk of a nursing mother has not been studied, in connection with which, its purpose in the period lactation possible only with a positive comparison of the benefits of such treatment for the mother in comparison with the possible risks for the newborn.

Reviews about Klindatsin

Most women who use this drug for treatment bacterial vaginosis, I leave positive reviews about the clindacin suppositories, including patients forced to resort to this drug with pregnancy in the II and III trimester. Reviews about Klindacin cream are not so numerous, but they are also positive in terms of the effectiveness and safety of this therapeutic drug. Summarizing the general impression of patients about Klindacin therapy bacterial vaginosis, it is safe to recommend it for use according to indications, but only after consulting a specialist.

Klindatsin's price where to buy

Compared with its counterparts for topical use (including vaginal ointments, creams, suppositories, capsules, etc.), the cost of clindacin is at a high level. For example, price Klindatsina in the candles No. 3 is about 650 rubles (respectively, 6 candles can be purchased on average for 1300 rubles). Price clindacin cream varies between 350-400 rubles per tube of 20 grams.

  • Online Pharmacies in Russia

ZdravCity

  • Clindacin B Prolong Cream Vag. 2% + 2% tube 20gAO Akrikhin499 rub.order
  • Clindacin supp. vag. 100mg n3Pharmaprim / Akrikhin520 rub.order
  • Clindacin cream vag. 2% 20gJSC Akrikhin420 rub.order

Pharmacy Dialog

  • Clindacin cream (tube 2% 20g (vag.)) 486 rub.
  • Clindacin B prolong cream creme vag. (2% + 2% tube 20g) 579 rub. Order
  • Klindatsin candles (supp. Vag. 100mg No. 3) 597 rubles to order

Eurofarm * 4% discount on the promotional code medside11

  • Clindacin b Prolong vaginal cream 20 gHFC "Akrikhin" 620 rub. Order
  • Clindacin vaginal suppositories 100 mg n3Pharmaprim / Akrikhin660 rub.order
  • Clindacin vaginal cream 2% 20 g Akrikhin HFK OJSC499 rub. Order
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Watch the video: Clindacin Plus Gel - what is clindamycin gel used to treat? Bangla (February 2020).

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