The preparation contains the active substance: doxycycline.
Additional components: lactose, magnesium stearate, corn starch, sodium lauryl sulfate, alginic acid.
Vibramycin is available in the form of capsules, packaged in blisters of 10 pieces, one blister per pack.
Vibramycin exhibits antibacterialact.
Pharmacodynamics and pharmacokinetics
For the drug Vibramycin is characteristic bacteriostaticthe action of inhibiting protein biosynthesis at the ribosomal level.
Various gram-positive and gram-negative microorganisms, as well as strains that show resistance to others, are highly sensitive to doxycycline. antibioticsfor example, to new penicillins or cephalosporin. Particularly sensitive are Haemophilus influenzae - more than 90% and the main intracellular pathogens.
The drug actively affects many pathogens of dangerous infections: plague, tularemia, legionella, anthrax, brucella, cholera vibrio, glanders, rickettsia, chlamydiaand others. Some strains of Proteus, Pseudomonas aeruginosa, and mushrooms are not sensitive to it.
It has been established that this antibiotic to a lesser extent has a depressing effect on the intestinal flora, is better and more fully absorbed, and retains the effect longer. Moreover, the antibacterial activity of doxycycline is higher than that of other natural tetracyclines.
Eating does not affect doxycycline absorption. The drug is characterized by a high degree of solubility of the main substance in lipids, as well as low affinity, aimed at binding Ca2 +. The medicine is quickly and fully absorbed from the digestive tract, depending on the dosage taken. The maximum concentration in the plasma is reached after 2 hours from the moment of taking a dose of 200 mg.
Communication of Vibramycin with proteins blood is at least 93%. Inside the body, the drug is well distributed in organs and tissues, the accumulation of therapeutic concentrations is detected after 30-45 minutes from the time of administration. Marked weak penetration into the cerebrospinal fluid. The drug is able to penetrate through the placenta and into breast milk. The substance is excreted from the body with feces and urine.
Indications for use
The drug is prescribed in the treatment of various infections affecting the activity of:
- respiratory organs, for example, with pharyngitis, bronchitis and pneumonia, as well as ENT organs - with otitis media, tonsillitis, sinusitis and other violations;
- genitourinary system with non-chronic urethritis, cervical inflammation, pelvic infections, epididymitis, proctitis, venereal granuloma.
As well as conjunctivitis, typhus, fever, gonorrhea, syphilis, cholera, chancre, trachoma, psittacosis, brucellosis, plague and so on.
Vibramycin is not recommended for:
- hypersensitivity to its components;
- severe hepatic and renal failure;
- Patients less than 8 years old;
- systemic lupus erythematosus;
- lactation, pregnancy;
Taking this drug may cause side effects that affect the functioning of the nervous and digestive systems, development allergic reactions, as well as other undesirable actions. In this case, symptoms may appear in the form of: dizzinessloss appetite, nausea, vomiting, diarrhea, glossitisinflammation of the mucous membranes of the oral cavity and other places, gastritis, esophagitis, pseudomembranous colitis and hepatotoxicity.
Sometimes a long or repeated treatment causes the development of superinfection due to the propagation of bacteria or fungi insensitive to the drug.
Also, the appearance of undesirable skin symptoms is not excluded: a change in skin color, rash, dermatitis and so on. Allergic reactions may occur with a rash, urticariaeosinophilia shortness of breathanaphylaxis angioedema and other violations.
Adult patients often experience an increase in intracranial pressure, headache, nausea, vomiting, visual impairment.
Vibramycin, instructions for use (Method and dosage)
The dose of the drug and the duration of treatment are determined by the attending physician. The average daily dosage for adult patients is 200 mg at the beginning of treatment, then a maintenance dose of 100 mg can be established. It should be noted that for each type of violation, an appropriate regimen and duration of treatment are prescribed.
Capsules are swallowed in their entirety, abundantly washed down with liquid. Absorption of the drug improves when taken on an empty stomach.
When skipping the next capsule, you must take the missed dose as quickly as possible. But if a lot of time has already passed, then it is better to continue using the medicine according to the prescribed scheme. A double dose is not allowed!
With an overdose of doxycycline, symptoms related to side effects may intensify. This requires the accelerated removal of drug residues from the digestive tract by gastric lavage, taking activated carbon.
Additional symptomatic therapy may also be performed, accompanied by monitoring and maintenance of basic body functions.
The combination of doxycycline with antacids containing Al3 +, Mg2 +, Ca2 +, as well as iron, sodium bicarbonate preparations, laxatives with magnesium, cholestyramine and colestipol can reduce their effect, therefore, between the use of such drugs observe an interval of 3 hours.
Suppression intestinal microflora able to reduce the prothrombin index, requiring dosage adjustment of indirect anticoagulants.
The drug enhances the effectiveness of anticoagulant derivatives of coumarin, some antidiabetic agents that are derivatives of sulfonylurea. With simultaneous use, a reduction in the doses of these drugs is often required.
Combinations with bactericidal antibiotics disrupt cell wall production, for example, with penicillins and cephalosporins, reducing their effectiveness.
Vibramycin can reduce the effectiveness of many oral contraceptives. Therefore, treatment with doxycycline requires additional effective methods of contraception.
When combined with Retinol often increases intracranial pressure.
Vibramycin increases toxic effects Methotrexate or Cyclosporina A.
Concomitant use with barbiturates, carbamazepine, diphenylhydantoin accelerates metabolism the main substance, reducing its half-life and reducing the therapeutic effect. Therefore, it is possible to increase the daily dosage of doxycycline.
Theophylline able to cause side effects affecting the digestive tract.
To prevent the local irritating effect of the drug, for example, esophagitis, gastritis, gastrointestinal ulceration, it is better to take it in the daytime, drinking plenty of fluids.
The development of photosensitization is possible, therefore, it is necessary to limit the insolation of treatment before and after it for 4-5 days.
Sometimes the drug masks symptoms syphilisthat requires a monthly serological analysis for 4 months. The use of Vibramycin can affect the results of glucose, urobilinogen, catecholamines and protein in the urine.
Treatment with doxycycline can lead to the development of allergic manifestations and resistant microorganisms such as Candida. If undesirable symptoms and infections caused by resistant microorganisms occur, the drug is canceled and appropriate treatment is started.
Various antibiotics with a wide spectrum of action can cause pseudomembranous colitis. With inhibition of the normal bacterial flora of the gastrointestinal tract, the stick of Clostridium difficile can develop, toxic substances of which cause pseudomembranous colitis. The appearance of a digestive disorder requires a doctor, and not an independent treatment. It is recommended to refrain from the use of drugs that can inhibit intestinal motility and other fastening agents.
Terms of sale
Capsules should be stored in a dry, dark, cool and out of the reach of children.
Vibramycin analoguesMatches for ATX Level 4 code:Doxycycline hydrochlorideDoxycyclineUnidox SolutabOletetrin
The main analogues are represented by drugs: Vidoktsin, Dovitsin, Doksal, Doksibene, Doksibene M, Doksilan and Doxycycline.
When combined with alcohol, it is possible to accelerate the metabolism of doxycycline, which can shorten the half-life of the substance, reducing its therapeutic effect.
Reviews on Vibramycin
As numerous reviews of drugs created on the basis of doxycycline show, a large number of patients took them. Moreover, almost everyone notes its high efficiency. In general, the therapeutic process of various infections is quite complex, implying a comprehensive and certainly individual approach. It all depends on many factors, and not the type of drug.
It should be noted that reviews of Vibramycin are not common. Usually, doctors prescribe other drugs, for example, Doxycycline, Unidox Solutab, and so on. Therefore, taking antibiotics can be both highly effective and useless, and sometimes even dangerous.
Often, patients are interested in where you can buy Vibramycin tablets, as well as Vibramycin D. Also, the action of this group of antibiotics is actively discussed at various sites and forums. Often, users compare which of the drugs is more effective, the dosage regimen and dosage.
In any case, the use of antibiotics is unacceptable without a doctor's prescription. As you know, self-medication often leads to undesirable consequences. When prescribing antibiotics by a doctor, you need to specify how to reduce their adverse effect on the body. These can be a variety of measures and procedures, so they should be discussed before treatment begins.
Vibramycin price, where to buy
Buy Vibramycin in Russian pharmacies is not easy, so specialists usually prescribe their substitutes.
These include Doxycycline at a price of 14 rubles, as well as Unidox, which costs from 253 rubles.
- Online pharmacies in UkraineUkraine
- Vibramycin D 100 mg No. 10 tablets Fareva Amboise, France 169 UAH
- Vibramycin D tablets Vibramycin D tablets dispersible 100mg No. 10 France, Fareva Amboise 182 UAH order