In one capsule Silibor max contains 35, 70 or 140 mg silibora. Using silymarin its amount is taken in terms of 100% of the sum flavolignans(silymarin) Crospovidone, as well as calcium stearate and lactose monohydrate monohydrate are excipients.
The excipients in the tablets are potato starch, sodium starch glycolate, calcium stearate, lactose monohydrate, hypromellose, titanium dioxide, yellow dye "Sunny Sunset" (E110).
Silibor 35, 70 and 140 are available in capsules, which by their physical properties are hard and gelatinous, have a caramel color. Inside the capsules is a mixture of granules and powder, which is usually light yellow or brownish in color, possibly agglomerating particles. A trademark may be present on one side of the capsule - ZT.
Also, the drug is available in orange or brownish tablets with acceptable marble splashes. They have a shell and 2 layers are visible in the transverse section.
Characteristic for the drug hepatoprotectiveproperties as well antioxidantactivity, can stimulate protein synthesis and normalize the metabolism of phospholipids.
Pharmacodynamics and pharmacokinetics
Hepatoprotectiveinfluence based antioxidantand membrane stabilizingactivity of the drug. Improving the metabolism in hepatocytes is on the path to normalizing the metabolism of phospholipids and stimulating the synthesis of structural and functional proteins, glycogen and RNA. Protection against the penetration of hepatotoxic substances into hepatocytes accelerates the recovery processes of the liver.
Characterization of the pharmacokinetics of the drug
The process of absorption from the gastrointestinal tract is slow, the half-absorption period is approximately 130 minutes. Metabolism is carried out in the liver by conjugation. Approximately 40% excreted along with bile silymaringoes into the cycle of portal-biliary circulation of bile acids. Excretion mainly with bile in the form of sulfates and glucuronidesthe rest with urine. It does not accumulate in the body and tissues. The half-life of the drug is up to 6 hours.
Indications for use
Silibor tablets are usually prescribed:
- at chronic hepatitis, as well as cirrhosis of the liver of various origin (in complex therapy);
- at steatohepatosis;
- to prevent the threat of negative external effects of hepatotoxic substances and prolonged use of drugs that worsen the functional state of the liver.
- hypersensitivity to the active and auxiliary components of the drug;
- children's age - patients under 6 years old.
- dyspeptic disorders: diarrhea;
- allergic reactions: skin rash, itching;
- increase diuresis;
- dizziness (most often with prolonged treatment).
Attention! If any of the undesirable side symptoms is detected, then you should consult a doctor to adjust the dose or completely discontinue the drug.
Silibor, instructions for use (Method and dosage)
Silibor should be taken before meals, and do not chew and drink with a small amount of water. The dosage for different groups of patients in the treatment of various liver diseases is different:
- adults and children from 12 years old - 210 mg for 3 doses during the day;
- patients with severe forms of the disease: the daily dose, if necessary, can be increased to 420 mg in 3 divided doses;
- children aged 6–9 years: 70 mg at a time;
- children 9-12 years old - 140 mg in 2 divided doses throughout the day.
The standard course of treatment should last at least 1 month, as prescribed by the attending physician, can be extended up to 3 months. Repeat therapy is allowed after 1-2 months.
As a prophylactic
The daily dose is 70 mg 1-2 times a day. Duration of admission is up to 1 month.
Cases of taking overdoses of Silibor have not been previously reported and described.
The first measures for an overdose of the drug
First you need to induce vomiting, take Activated carbonif necessary, conduct symptomatic therapy.
No clinically significant reactions of drug interactions with other known drugs were found.
Terms of sale
It is released without a prescription.
Store recommended in a cool, dry place protected from sunlight (temperature within 8 ˚- 25˚Celsius). In addition, it is necessary to find a place out of the reach of children.
Estimated shelf life is two years.
During pregnancy and lactation
Therapy can be carried out only under the condition of potentially greater benefit to the mother than the alleged negative effects on the child or fetus. In addition, the control of a doctor is necessary, because an increase in diuresis is possible, which is caused by a slight diuretic effect characteristic of flavonoids.
AnalogsMatches for ATX Level 4 code:HepatosanSireparHepatomaxPhosphoglivPhosphogliv ForteCarsil ForteGalstenaDarsilEssential Forte NEssentialeLivolin ForteKarsilEspa liponErbisolSilimarRemaxolLecithinEnergyliveLaenneckProgepar
Reviews on Silibor
On the forums, this drug is most often advised when biliary dyskinesiaas well as when taking strong antibioticsas a powerful hepatoprotective agent.
Silibor price where to buy
A pack of Silibor 35 tablets (25 tablets) can be bought for 18.9-21.2 UAH.
- Online Pharmacies in Russia
- Online pharmacies in UkraineUkraine
LuxPharma * special offer
- Silibor tab. 35mg 25pcs
- Silibor max capsule Silibor 140 caps. 140 mg №20 Ukraine, Health LLC 90 UAH order
- Silibor forte capsule Silibor 70 caps. 70mg №20 Ukraine, Health LLC 49 UAH order