1 bottle includes 500,000 units or 1,000,000 units benzylpenicillin sodium salt (benzylpenicillin).
The company "Synthesis" produces the drug in the form of a powder for injection, in bottles No. 1; No. 5; No. 10 or No. 50 per pack.
Pharmacodynamics and pharmacokinetics
Benzylpenicillinis biosynthetic antibiotic and the group enters penicillins. The bactericidal effectiveness of the drug is manifested due to its ability to inhibit wall synthesis. bacterial cells.
The effect of the drug is detrimental to gram-positive microorganisms: staphylococcuspathogens diphtheriaand anthrax, streptococcus; gram-negative bacteria: pathogens gonorrhea and meningococcal infection; spore-forming anaerobic rods; as well as spirocheteand actinomycete.
Not sensitive benzylpenicillinstrains staphylococcusthat produce penicillinase.
With the introduction of the drug in / m TCmax in plasma is observed after 20-30 minutes. Binding to plasma proteins occurs at 60%. Antibioticdiffers in good penetration into tissues, biological fluids and organs of the human body, with the exception of cerebrospinal fluid, prostate gland and ocular tissue goes through BBB. Excretion is carried out in unchanged form by the kidneys. T1 / 2 ranges between 30-60 minutes, with kidney pathologiesmay increase up to 4-10 hours or more.
Indications for use
Benzylpenicillin is indicated for the treatment of diseases that were caused by microorganisms sensitive to its effects:
- focal / croupous pneumonia;
- empyema of pleura;
- scarlet fever;
- septic endocarditis (subacute and sharp);
- ENT infections;
- biliary and urinary tract infections;
- infections of the mucous membranes and soft tissues;
- purulent skin infections;
- purulent-inflammatory infections in gynecologists.
Absolutely prohibited introduction benzylpenicillinwith personal hypersensitivity (including others penicillin antibiotics) and epilepsy (for endolumbar injection). Also do not recommend the use of this drug when breastfeeding and pregnancy.
The occurrence of effects associated with the chemotherapeutic effect of drugs, including oral candidiasis and / or vagina.
From the gastrointestinal tract, a feeling was observed nausea, diarrheasometimes vomit.
From the side of the central nervous system, especially when using high doses of the drug or when injecting endolumbally, the formation of neurotoxic phenomenasuch as an increase in reflex excitability, crampsnausea symptoms meningismvomiting coma.
Celebrated allergic manifestations were temperature riseoccurrence skin rash and / or mucosal rash, urticariajoint pain angioedema, eosinophiliais also possible anaphylactic shockthat can lead to fatal.
Benzylpenicillin sodium salt, instructions for use
Dosage regimen benzylpenicillinset individually. Intramuscular (in / m), subcutaneous (s / c), intravenous (in / in) and endolumbar administration of the drug are practiced.
In the case of IM and IV injections, the daily dosage for adult patients varies in the range of 250,000-60000,000 units. Generally used Benzylpenicillin sodium salt 1,000,000 units.
The daily children's dose is calculated based on the weight of the child and is 50,000-100,000 units per kilogram of weight for children under the age of 1 year and 50,000 units per kilogram of weight for children after the 1st year. According to indications, it is possible to increase the daily dosage to 300,000 units per kilogram of weight, according to vital indications - up to 500,000 units per kilogram of weight. The introduction of the drug is carried out 4-6 times in 24 hours.
Basically, for IV and IM injections, the powder is diluted in water d / in. Also, in oil applications, it can be dissolved in novocaine (0.5%), with a preliminary test for the sensitivity of the patient to it. Before you breed Benzylpenicillin sodium salt, powder should be visually checked for foreign matter. The prepared solution can be stored for no more than 24 hours.
SC administration of an antibiotic is practiced for chipping infiltrates. In this case, 100000-200000 ED powder is dissolved in 1 ml novocaine(0,25-0,5%).
Endolumbal injections are carried out based on the disease and its severity. Adult doses are 5000-10000 UNITS, for children - 2000-5000 UNITS. In this case, the dilution of the powder is carried out water d / in. or solution sodium chloride (0.9%) at the rate of 1000 PIECES per 1 ml of solvent. Before administration, depending on indicators intracranial pressure5-10 ml should be extracted CSFand add to the prepared solution of the drug in a ratio of 1: 1.
The minimum duration of treatment is limited to 7 days, the maximum can last up to 2 months or even longer.
In case of overdose benzylpenicillinnoted its toxic effect on the central nervous system (mainly with the introduction of endolumbar). The observed symptoms were manifested reflex excitationnausea headaches, myalgiavomiting spasms, meningismarthralgia coma.
In this situation, further injections are stopped and symptomatic treatment is prescribed, including hemodialysis. In this case, special attention is paid to the water-electrolyte state.
Combined appointment with bacteriostatic antibiotics (Tetracycline), reduces bactericidal efficacy benzylpenicillin.
Concurrent use with Probenecid reduces tubular secretion benzylpenicillin, which affects the increase in its plasma concentration and increases T1 / 2.
Terms of sale
Benzylpenicillingoes on sale as a prescription drug.
Powder should be stored in its original sealed vial at temperatures up to 20 ° C.
From the date of manufacture - 3 years.
Benzylpenicillinprescribed with extreme caution to patients with kidney pathologies, heart failureallergies (especially with drug allergies), as well as hypersensitivityto cephalosporin(due to the possible formation of cross-reactions).
In case of zero effect of the therapy carried out during 3-5 days, it should be considered the possibility of a combination with other drugs or the appointment of other antibiotics.
May develop during treatment fungal superinfection, in connection with which it is advisable to parallel use antifungal agents.
It should be remembered that early termination of treatment benzylpenicillinor its use in subtherapeutic doses contributes to the formation of resistant bacterial strains.
AnalogsMatches for ATX Level 4 code:BicillinPhenoxymethylpenicillinExtensillinRetarpenBenzylpenicillinSulacillin
- Star pen.
Treatment of children is carried out in the above doses, calculated in accordance with their weight.
It is better to avoid drinking alcohol.
During pregnancy and lactation
Appointment benzylpenicillinat pregnancy allowed only in extreme cases, with a comprehensive assessment of the benefits / risks.
If necessary benzylpenicillinat the time of lactation, breast-feeding stop it.
On various Internet resources you can find both negative and positive reviews about Benzylpenicillin sodium salt. In the case of the use of the drug against sensitive to it microorganisms the treatment almost always shows high results and, conversely, when using Benzylpenicillinto destroy resistant to its effects bacteria strains, at best, is wasted. In this regard, for any bacterial infection it is better to identify it before therapy pathogenand only then assign relevant in this case antibiotic.
Price, where to buy
The price of Benzylpenicillin sodium salt at 1,000,000 units is 6-7 rubles per 1 bottle.
- Online pharmacies in UkraineUkraine
- Online pharmacies in Kazakhstan
- Benzylpenicillin vial Benzylpenicillin sodium salt powder for injection 1000000ED Ukraine, Kievmedpreparat OAO 11 UAH order
- Benzylpenicillin crystalline sodium salt 1 mln. UNITS No 1 (50pcs per core) pores. d / in.f. Synthesis of OJSC (Russia) 70 tenge
- Benzylpenicillin crystalline sodium salt 1 mln. UNITS No 1 (50pcs per core) pores. d / in.f. Biochemist (Russia) 70 tg.order