Medication

Loperamide Hydrochloride

Structure

1 capsule includes 2 mg loperamide hydrochloride - active ingredient.

Additional components: milk sugar, corn starch, magnesium stearate.

Release form

Company "Health to the people»Produces Loperamide Hydrochloride in capsule form, 10 or 20 pieces per pack.

Pharmachologic effect

Antidiarrheal.

Pharmacodynamics and pharmacokinetics

Loperamide hydrochloride is antidiarrheala drug whose effectiveness is inhibition intestinal motility. The effect of the drug is manifested due to the binding of its active ingredient to opioid receptorslocated in the intestinal wall, as a result of which the release is suppressed prostaglandin E2α and acetylcholine. As a result of such exposure, the progression of intestinal contents and its peristalsisand also extends the time electrolyte absorption and water. In addition to this, the drug has antisecretoryaction reduces urge to defecateincreases anus sphincter tone and helps to contain feces.

T1 / 2 of the drug on average equals 11 (from 9 to 14) hours. Communication with plasma proteins (mainly with albumin) is at the level of 95%. Elimination is carried out due to oxidative N-demethylation, which is the main way of the metabolic transformations of the drug. It is removed from the human body mainly with feces.

Indications for use

The use of loperamide hydrochloride is indicated for symptomatic treatment of diarrhea chronic and acute.

It is possible to use the drug for prevention with diarrhea of ​​travelers. In this case, therapy should last at least 48 hours. Only when detected in feces blood drug intake should be interrupted, until the exact establishment of the cause of this phenomenon.

Contraindications

It is not allowed to prescribe the drug with:

  • pathologies associated with sugar intolerance;
  • personal hypersensitivityto loperamide hydrochloride or other components of the tablets;
  • pseudomembranous colitis or spicy ulcerative colitisdeveloped due to the previous antibiotic therapy;
  • acute dysentery(with manifestations of fever and the presence of blood in the stool);
  • bacterial enterocolitisdue to exposure to bacteria of childbirth Campylobacter, Shigell and Salmonell;
  • liver pathologies;
  • children under 6 years old.

Side effects

The immune system:

  • anaphylactoid reactions;
  • anaphylactic shock.

Nervous system:

  • insomnia/drowsiness;
  • headache;
  • cramps
  • fatigue;
  • tremor;
  • dizziness;
  • oppression/loss of consciousness.

Digestive system:

  • colic/crampingin a stomach;
  • nausea/vomiting;
  • ileus;
  • constipation;
  • forced formation of toxic megacolon;
  • dyspepsia;
  • dry mouth
  • flatulence;
  • intestinal obstruction (paralytic).

Urinary system:

  • urinary retention.

Skin:

  • erythema multiforme;
  • skin rashes;
  • hives;
  • Stevens-Johnson syndrome;
  • angioedema;
  • epidermal toxic necrolysis.

Instructions for use Loperamide Hydrochloride (Method and dosage)

According to the instructions for Loperamide Hydrochloride, the drug is intended for oral administration (oral), by patients who have reached 6 years of age.

At acute diarrhea shows an initial dose of 4 mg in adults and 2 mg in children. Subsequently, despite the patient’s age, it is recommended to take 2 mg of the drug after each liquid bowel movement.

At chronic diarrhea4 mg are prescribed daily for adult patients and 2 mg for children. In the future, you should individually select a maintenance dose of the drug, for which loperamide hydrochloride dosed so that the amount solid bowel movements per day was 1-2 times. In this case, the individual dosage regimen varies in the range of 2-12 mg in 24 hours.

At any manifestation diarrhea(chronic / acute) The maximum daily dosage for adults is considered to be 16 mg. For children, this dose is calculated based on their weight, in a ratio of 6 mg per 20 kg of body weight.

In the absence of clinical efficacy of treatment acute diarrhea within 48 hours, the drug should be discontinued.

For the treatment of elderly patients and patients with pathologies of the kidneys dosage adjustment is not required.

At liver pathologies the prescription of the drug should be carried out with caution, in connection with the possible slowdown of the metabolic transformations of the first passage.

The drug is not prescribed for initial therapy severe diarrheawhich proceeds with a decrease electrolyte level and body fluids. In childhood, such a loss should be compensated for by oral and / or parenteral replacement therapy.

Overdose

In case of violation of the dosage regimen and taking overestimated doses of the drug, the following can be observed: stupor, drowsinessviolation of coordination miosis, respiratory depressionhypertonicity of the muscles of the skeleton, urinary retentionas well as symptoms intestinal obstruction. Children are most susceptible to the effects of the drug on the central nervous system, due to a reason that does not fully function blood-brain barrier.

Antidote the drug is Naloxone. Due to the fact that loperamide hydrochloride valid for 1-3 hours longer Naloxone, you may need to re-use the antidote. To detect possible CNS suppression the patient must be under medical supervision for at least 48 hours. In parallel with antidotesymptomatic treatment, including gastrointestinal tract cleaning and reception sorbents.

Interaction

Combined use with anticholinergic drugs(atropine) causes a mutual increase in efficiency, and therefore it is better to avoid such a combination of drugs.

Do not carry out therapy loperamide hydrochloride when the patient uses drugs that suppress the central nervous system (especially for children).

Concurrent use of drugs that are inhibitors of P-glycoproteins (Ritonavir, Quinidine) and dosages loperamide hydrochloride close to maximum, increases the plasma level of the latter by 2-3 times. The relevance of this interaction to clinical therapy, in the dose range loperamide hydrochloride2-16 mg not established.

Terms of sale

Loperamide hydrochloride is supplied to pharmacies as an over-the-counter drug.

Storage conditions

It is necessary to adhere to the temperature regime of storage of capsules of the drug, which is up to 25 ° C.

Shelf life

From the date of manufacture - 3 years.

Special instructions

It is worth remembering that the application loperamide hydrochloride for treatment diarrheais symptomatic. In the case when the cause of diarrhea is accurately diagnosed, it is better to conduct targeted therapy using drugs indicated specifically for this disease state.

Purely on the background diarrhea, especially in children, is formed electrolyte imbalance and dehydration. When observing these phenomena, activities aimed at replenishing should be carried out in the first place electrolytesand liquidsin the body.

At reception loperamide hydrochloride for treatment diarrheain patients with the syndrome immunodeficiencyin case of detection of the first symptoms bloatingtherapy is stopped immediately. Also in patients Aidsnoted some facts of formation toxic megacolon with parallel infectious colitisas bacterialso viral etiology.

Despite the absence of deviations in pharmacokinetic parameters loperamide hydrochloride in the treatment of patients with liver pathologies, in this group of patients, the drug should be prescribed with caution, due to a slowdown in the metabolic transformations of the first passage. For the timely detection of possible symptoms toxic damage to the central nervous system such patients should be constantly monitored.

Due to the presence in the preparation lactose, its reception is forbidden to patients with sugar intolerance.

In case of formation bloating, constipationpartial intestinal obstruction, as well as megacolon, diverticulosisenterocolitis associated with exposure bacteriakind salmonelladiscontinue therapy immediately.

Analogs

Matches for ATX Level 4 code:LoperamideImodium PlusImodiumLopedium
  • Loflatil;
  • Diaremix;
  • Uzara;
  • Imodium Plus.

Synonyms

  • Stopoperan;
  • Lopedium;
  • Imodium;
  • Diara;
  • Superlope.

For children

Prescribing the drug to children under 6 years of age is prohibited.

During pregnancy and lactation

Data about embryotoxicand teratogenic influence loperamide hydrochloride are absent. Despite this, during of pregnancy, especially in the first trimester, the appointment of the drug is permissible only in the case of a significant excess of the positive effect for the mother compared with the possible risk to the fetus / child.

A certain amount of the drug is found in milka nursing mother, in connection with which, when taking it, it should be suspended breast-feeding.

Reviews

Looking through reviews about loperamide hydrochloride, it should be remembered that this drug is mainly intended for symptomatic treatment of diarrhea for a short period of time. In case of her bacterial, exudative, invasiveetc. of origin, the drug will be at least ineffective, and in some cases can lead to masking the symptoms of the pathological process and, as a result, to the progression of the disease.

Price, where to buy

The price of 20 capsules of the drug produced by "Health to the people", Makes 6-8 hryvnias.

  • Online pharmacies in Kazakhstan

BIOSPHERE

  • Loperamide hydrochloride 2 mg No. 10 caps. Borisov ZMP (Belarus) 80 tg.order
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Watch the video: Loperamide tablet हनद म drug for diarrhea. dose, side effects and warnings (January 2020).

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