1 gram of gel includes 600 mcg estradiol - active ingredient.

Additional components: carbomer, ethanol, trolamine, purified water.

Release form

Estrogel is available in gel form in tubes of 80 grams with a dispenser (1 dose is 2.5 grams of gel, including 1.5 mg of estradiol).

Pharmachologic effect

Hormonal (supplementing deficiency estrogen).

Pharmacodynamics and pharmacokinetics

Gel Estrogel, thanks to its active ingredient - estradiol (estrogen), is a drug with estrogen activity intended exclusively for external (local) use.

Against the background of therapy with the use of estrogen, the manifestations are significantly reduced menopausal syndrome (including depressive states, tides, hyperhidrosis, vaginal dryness) According to the clinical productivity of treatment postmenopausal symptoms Oestrogel is not inferior to oral therapy estrogen preparations. In addition, when using the drug during menopause there is a slowdown in processes that reduce bone density.

The treatment also helps to reduce the level of total cholesterolpassing without deviations HDL / cholesterol.

Among other things, Estrogel has procoagulant efficiency, reduces content antithrombin III and increases liver synthesis vitamin K-dependent blood coagulation agents (II, VII, IX, X).

During the application of Estrogel, rapid evaporation occurs ethanol and as a result penetration estradiol through the skin. In this case, most of the drug immediately enters the systemic circulation, and its residual amounts remain in the subcutaneous fat, where they are also gradually released into the systemic circulation.

For topical use, Cmax Plasma Gel estradiol observed after 180-240 minutes. Bioavailability is at 82%.

Outdoor application estradiol leads to the fact that the drug is not exposed to the phenomenon of "first pass", resulting in a higher plasma concentration estradiol, in comparison with its oral counterparts.

Metabolic transformations estradiol and its further excretion, when using the preparation in the form of a gel, are comparable with those for natural estrogen.

Indications for use

The use of estrogen is recommended to reduce or eliminate symptoms. menopausal syndrome (including artificially induced menopause), as well as for prevention and therapy osteoporosis during the period postmenopausal women.


Estrogen is absolutely contraindicated for use in:

  • ischemic/hemorrhagic stroke;
  • pregnancy
  • sharp thrombophlebitis or thromboembolism;
  • rotor syndrome;
  • uterine bleeding uncertain etiology;
  • renal failure;
  • Dubin-Johnson syndrome;
  • estrogen-dependent malignant tumors or suspicions of their presence;
  • breastfeeding;
  • benign / malignant pituitary tumors;
  • hypersensitivity;
  • serious liver pathologies in the acute period, jaundice, liver tumors.

With extreme caution, the use of Estrogel is possible with:

  • Ischemic heart disease;
  • impaired hepatic function;
  • leiomyoma;
  • diabetes;
  • endometriosis;
  • migraine;
  • pancreatitis;
  • bronchial asthma;
  • family hyperlipoproteinemia;
  • inflammatory diseases of the reproductive system in women;
  • previously observed jaundice (including its manifestations during the past pregnancy);
  • epilepsy;
  • hepatic porphyria;
  • arterial hypertension in severe form;
  • thrombosis, thrombophlebitis or thromboembolism a history of estrogen therapy;
  • hypercalcemiaassociated with bone metastases in breast cancer;
  • pathologies of the gallbladder, in particular cholelithiasis (in the anamnesis);
  • circulatory disorders.

Side effects

Local manifestations:

  • skin hyperemia;
  • skin irritation.


  • headache/migraine;
  • dizziness;
  • mood swings.

The reproductive system:

  • an increase in size and / or increased sensitivity of the mammary glands;
  • soreness;
  • amenorrhea;
  • menorrhagia;
  • breakthrough bleeding;
  • spotting from the vagina during intermenstrual periods;
  • increased libido;
  • neoplasms at mammary glands.

Digestive system (rarely due to the lack of the phenomenon of "first passage" through the liver):

  • gallbladder obstruction;
  • vomiting of central origin (usually when using an overestimated amount of gel);
  • dyspepsia;
  • hepatitis;
  • nausea;
  • pancreatitis;
  • pain in the epigastric region;
  • anorexia;
  • cholestatic jaundice;
  • flatulence;
  • cholelithiasis;
  • diarrhea;
  • gastrointestinal spasms (including intestinal / biliary colic).


  • intolerance to contact lenses;
  • peripheral edema;
  • thromboembolism;
  • weight change;
  • allergic manifestations (including urticaria and itching of the skin);
  • increase in blood pressure;
  • contact dermatitis.

All these side effects are most often poorly expressed, mainly manifested in the initial stages of treatment and rarely require discontinuation of the drug.

Estrogel, instructions for use

Estrogel is used only externally, in a cyclic or continuous mode of application. The duration of treatment and the dosage of the gel is selected individually.

1 dose of gel (2.5 g) includes 1.5 mg of estradiol.

When using the gel, a one-time daily application of its first dose with a thin layer on the skin of the lumbar region, abdomen, forearms or shoulders is shown until absolute absorption. The area of ​​the skin on which the gel is applied should be at least the area of ​​both palms of the patient.

The correct application with the most effective result is the procedure in which the complete absorption of the gel occurs in 2-3 minutes. Maintaining a sticky consistency of one dose of the drug for more than 5 minutes after its use means an insufficient area of ​​the skin used.

Estrogel should be used by the woman herself, in the morning or evening hours, preferably on previously cleansed skin.


If oversized gel dosages are used, nausea, from vomiting with or without her as well as development uterine bleeding.

When these manifestations are formed, the use of the gel is stopped and treatment corresponding to the observed symptoms is prescribed.


In case of parallel reception with antihypertensive drugsindirect anticoagulants and hypoglycemic drugs may decrease their effectiveness, which may lead to a review of the dosage regimen.

The combined use of estrogen and lipid-lowering drugs leads to increased effectiveness of the latter.

When combined with drugs that are inducers of microsomal hepatic enzymes (including Rifampicin, Griseofulvin, Carbamazepine, barbiturates) there is a decrease in plasma content estradiol.

Using estrogel reduces effectiveness diuretics (diuretics) and male sex hormones.

Joint application opioid analgesics, tranquilizers and drugs used for general anesthesiaaccelerates metabolism estradiol.

Combined use with some antibiotics (including Rifampicin, Ampicillin) and Phenylbutazone reduces plasma concentrations estradiol.

Concurrent therapy hormonal drugs thyroid glandand folic acid enhances effects estradiol.

Terms of sale

Buying Oestrogel requires a prescription.

Storage conditions

The preservation of the gel requires a temperature regime of its storage up to 25 ° C.

Shelf life

From the moment of production - 3 years.

Special instructions

Before using Estrogen, a woman must undergo a complete gynecological examinationand in case of prolonged use of the gel, such an examination should be carried out at least once every 12 months.

On the recommendation of a gynecologist, it is advisable to conduct treatment estradiol in conjunction with gestagen therapy. This drug combination has protective properties against endometrium.

It is necessary to protect the mucous membranes of the vagina and vulva, as well as the skin in the area of ​​the mammary glands from getting gel on them.

Prolonged use of Oestrogel, especially at high dosages, increases the likelihood of endometrial cancer and breast.

Glandular or atypical hyperplasia often a harbinger endometrial cancer.

If necessary, a planned surgical intervention, treatment estrogen should be discontinued 4-6 weeks before surgery.

Estrogel does not possess contraceptive action and does not protect against pregnancy.

In case of detection in a patient jaundice, thrombosis, migraine-like pain, thromboembolismsignificant increase blood pressure, visual impairment, the use of Oestrogel is immediately stopped, until these conditions are fully diagnosed.

On the background of estrogen therapy, the occurrence in patients with intact uterus irregular menstrual flow may require a procedure diagnostic curettage, in order to exclude the formation uterine cancer.

When prescribing Estrogen, it is necessary to constantly monitor blood pressure, liver function and level glucose at blood (at diabetes).


Matches for ATX Level 4 code:KlimenCinestrolKlimaraColpotrophinProginovaEstrofemEstriolDivigelOvestinMicrofollin
  • Esterlan;
  • Ovestin;
  • Estrovagin;
  • Sinestrol;
  • Ethinyl estradiol;
  • Colpotrophin;
  • Elvagin;
  • Pausogest;
  • Ovipol Clio;
  • Estrokad;
  • Klimen;
  • Estrokad.


  • Klimara;
  • Estrofem;
  • Divigel;
  • Proginova;
  • Menostar;
  • Estramon 50;
  • Estradiol dipropionate.

For children

Due to the specificity of the indications for use, estrogen is not prescribed to children.

During pregnancy and lactation

Do not use estrogel when pregnancy and breastfeeding.


Women using this drug for the purpose of stopping menopausal symptoms, mostly leave positive reviews about Ostrozhel and note the rather high effectiveness of the drug, as well as the lower frequency and severity of side effects compared with its oral counterparts. Among the positive qualities of the gel mention its convenient dosage mechanism, rapid absorption into the skin, the absence of a sticky sensation after the application procedure and stains on clothes.

Price, where to buy

The average price of Estrogel varies around 700 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine


  • Oestrogel transdermal gel 0.6 mg / g vial 80g (with pump-dispenser) Bezen Menyufekchuring Belgium854 rub.order

Pharmacy Dialog

  • Estrogel gel (fl. With a dose of 80 g) 814 rubles to order

Eurofarm * 4% discount on the promotional code medside11

  • Estrogel gel transdermal 80 g Bezen Menyufekchuring Belgium CA1120 rub.order
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  • Oestrogel 0.6mg / g 80g gel Bezen Menyufekchuring Beldzhum SA, Belgium 335 UAH to order

Pani Pharmacy

  • Estrogel gel Estrogel gel 80g + doses. device No. 1 Belgium, Besins Manufacturing Belgium 404 UAH to order
  • Estrogel gel Estrogel gel 80g + spar. dozat. №1 Belgium, Besins Manufacturing Belgium 415 грн.order
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