One tablet contains the active substance isosorbide dinitrate in the amount of 0.01 g

Release form

Available in tablets.

Pharmachologic effect


Pharmacodynamics and pharmacokinetics

It has a peripheral effect on venous vessels. Under the influence of the drug Nitrosorbide, the oxygen demand of the heart muscle is reduced. The effect is achieved by reducing preload, afterload.

The drug has coronary expansion. Nitrosorbide reduces pressure in the ICC (pulmonary circulation), reduces blood flow to right atrium, reduces the severity of symptoms in pulmonary edema. Under the influence of the drug, redistribution of blood flow occurs in the area where blood circulation is reduced. In patients with coronary heart disease, the drug increases resistance to physical activity.

Nitrosorbide dilates blood vessels in the brain, headaches are possible. With prolonged use, it is noted cross tolerance to nitrates. After a break in treatment, the body's sensitivity to nitrosorbide is restored quite quickly.

After taking the tablets, nitrate begins to act after 5 minutes. There are prolonged forms of the drug, the effect of which develops after half an hour and lasts 12 hours.

Indications Nitrosorbide

What are the pills used for? The following indications are for use.

The medicine is used for the prevention, relief of attacks angina pectoris, with myocardial infarction, spasm of the coronary arteries, pulmonary edema, chronic heart failure, angiospastic retinitis, obliterating endarteritis.


Intravenous administration of nitrosorbide is not allowed with intracranial hypertensionhead injury (increases the level of intracranial pressure) constrictive pericarditis, heart tamponade, hemorrhagic stroke, hypovolemia.

With caution prescribed for acute myocardial infarction, thyrotoxicosis, severe anemia, glaucoma, arterial hypotension (accompanied by low systolic blood pressure), severe renal failure, during pregnancy, breastfeeding.

The tablet form is contraindicated in malabsorption syndromeincreased intestinal motility.

Nitrosorbide is not used in pediatrics.

Side effects

Nervous system: blurred visual perception, drowsiness, stiffness, decreased ability to fast motor activity, mental reactions, rarely observed brain ischemia.

Digestive systemdry mouth dyspeptic disordersburning tongue, nausea.

The cardiovascular system: tachycardia, drop in blood pressure, hyperemia of the skin of the face, dizziness, a feeling of heat, headaches.

Allergic reactions: rash, itching, hyperemia at the site of application.

Other side effects: exfoliative dermatitis, cross tolerance to other nitrates.

Instructions for use Nitrosorbide (Method and dosage)

Nitrosorbide tablets, instructions for use

2.5-5 mg, if necessary, repeat after 2 hours. An attack of angina pectoris is recommended to be stopped by sublingual administration of a tablet; when chewing, the vasodilating effect develops faster. With complex treatment chronic heart failure Nitrosorbide is taken 4 times a day for 10-20 mg.

Nitrosorbide preparations

Spray injected into the oral cavity during breath holding, 1-3 injections with an interval of 30 seconds. If there is no effect within 5 minutes, inhalation must be repeated. Before catheterization, 2 inhalations must be taken to prevent coronary spasm.

Parenteral administration: drip intravenously at a rate of 4 drops per minute, dosage calculation: 0.1 mg per ml. The maximum allowable rate of administration is 33 drops per minute.

With buccal administration plates with nitrosorbide are glued to the gums at the level of small molars or incisors, three times a day, the sides alternate.

Spray for application to the skin: spraying is carried out at a distance of 20 cm, 2 injections, the contents are rubbed with your fingertips.

Ointment applied twice a day at a dose of 1 g on the stomach, inner surface of the forearm, chest area. The minimum application area is 20 square centimeters.


In case of an overdose, visual disturbances, palpitations, fainting, dizziness, cramps, hyperthermia, sweating, anoxia, cyanosis, methemoglobinemia, dyspnea, hyperpnea, coma, paralysis, bradycardia, increased intracranial pressure.

An immediate gastric lavage is required, with the development of methemoglobinemia, a 1% solution is administered intravenously methylthioninium chloride at a dosage of 1-2 mg per kilogram.

With a drop in blood pressure, intravenously administered phenylephrine.


Alpha blockers, beta blockers reduce the antianginal effect. Verapamil, Nifedipine, Propranolol, amiodarone, vitamin C enhance the antianginal effect of the drug.

Simultaneous reception antipsychotic, vasodilating, antihypertensive drugs, ethanol, procainamide, tricyclic antidepressants, sildenafil, quinidine enhances hypotensive effect.

Envelope, astringent, adsorbents reduce absorption Isosorbide dinitrate.

M-anticholinergics in combination with nitrosorbide increase intraocular pressure.

Terms of sale

Recipe required.

Storage conditions

In a dry, cool, dark place inaccessible to children.

Keep away from fire.

Shelf life

Up to two years.

Special instructions

During the treatment period, it is recommended to regularly monitor the level of blood pressure and pulse.

In acute myocardial infarction, an attack of angina pectoris, the use of sublingual forms of the drug, or intravenous administration, is recommended. Long-term use of large dosages leads to the formation of tolerance, it is recommended to take breaks.

It is necessary to completely stop taking alcoholic beverages.

During pregnancy, breastfeeding, Nitrosorbide is prescribed solely for strict indications.

The drug is ineffective in toxic pulmonary edema, heart failure caused by cardiac tamponade.

Abrupt withdrawal of the drug is unacceptable, a gradual reduction in dosage is recommended.

Nitrosorbide reduces the speed of psychomotor, psychoemotional reactions, special care is required when managing complex mechanisms, driving a car.


Matches for ATX Level 4 code:NitrosprayNitroglycerineEfoxMonosanNitromintPectrolIsoketErinitCardicetSustak Forte

Analogs include drugs: Wild long, Isodyne, Isodinitrate, Isoket, Iso-Mick, Nitrosorbitol.


Cheap, high-quality, effective drug for heart attacks. Requires careful use, can also dramatically reduce pressure.

Nitrosorbide price, where to buy

The price of nitrosorbide in tablets of 10 mg is 25-35 rubles per pack of 50 pieces.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan


  • Nitrosorbide Tab. 10mg n60OOO Pharmapol-Volga33 rub.order

Pharmacy Dialog

  • Nitrosorbide (tab. 10mg No. 60) 30 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Nitrosorbide 10 mg No. 60 tablPHARMAPOL-VOLGA, LLC30 rub.order
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  • Nitrosorbide 0.01 N40 tablets PAT NEC "Borshchagіvsky Chemical and Pharmaceutical Plant", city of Kyiv, Ukraine11 UAH order
  • Nitrosorbide 10 mg No. 40 tablets PAT Monfarm, Ukraine 11 UAH order
  • Nitrosorbide 10 mg N50 tablets TOV "NVF" Mikrokhim ", Ukraine 11 UAH order

Pani Pharmacy

  • Nitrosorbide tablets Nitrosorbide tablets 0.01g №40 Ukraine, Borshchagovsky HFZ PAO 14 UAH to order
  • Nitrosorbide tablets Nitrosorbide tablets 10mg No. 50 Ukraine, Mikrokhim OOO 13 UAH order
  • Nitrosorbide tablets Nitrosorbide tablets 0.01g №40 Ukraine, Monfarm AO 13 UAH order
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  • Nitrosorbide 10 mg No. 10 tablets Hympharm (Kazakhstan) 185 tg.
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Watch the video: ايزورديل Isordil (January 2020).

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