Lem tablet contains 7.5 / 15 mg of active substance meloxicam.

Auxiliary components: aerosil (colloidal form of silicon dioxide), Mg stearate, lactose, starch (potato), croscarmellose Na, microcrystalline cellulose, polyvinylpyrrolidone.

Release form

The medicine Lem is available in the form of white tablets (a yellowish tint is allowed) of a flat-cylindrical shape. Tablets with a dosage of 15 mg are at risk. A slight marbling of tablets is possible. The blister packs 10 tablets. In a pack of cardboard there is an instruction from the manufacturer and 1-4 blisters.

Pharmachologic effect

Medication from the NSAID group. Active component meloxicam It has antipyretic, analgesic and pronounced anti-inflammatory effects. Anti-inflammatory effect is achieved by inhibiting the activity of the specific enzyme Cyclooxygenase-2, which takes part in biological synthesis prostaglandins in the focus of inflammation.

The specific component Cyclooxygenase-1 is less affected by the active component. COX-1 is involved in the synthesis of prostaglandins, which protect the mucous wall of the digestive tract and are involved in the regulation of blood flow.

Pharmacodynamics and pharmacokinetics


After taking per os, the active substance is absorbed from the lumen of the digestive tract. The absolute bioavailability index reaches 89%.

Food does not affect the absorption of the active substance. The concentration of the active component meloxicam after application of per os in doses of 7.5 and 15 mg are proportional to the amount of medication.


Regular use of the drug allows you to achieve an equilibrium state for 3-5 days. The concentration of the active substance during long-term therapy (more than 1 year) is similar to CSS, which is established after the first days of treatment. The indicator of communication with plasma proteins is more than 90%.

The active substance is able to pass through histohematological barriers. In synovial fluid, the concentration of the active component reaches 50% of the maximum concentration meloxicam in plasma. The Vd value is 11 liters.


As a result metabolism 4 metabolites are formed in the hepatic system that do not have pharmacological activity. The main one is 5-carboxymeloxicam, resulting from the oxidation of 5-hydroxymethylmeloxicam (an intermediate metabolite).

In-vitro studies have established that the process of biological transformation is carried out with the active participation of the isoenzyme CYP2C9 and passive - CYP3A4. The formation of two other metabolites is carried out with the participation of peroxidase, the activity of which varies depending on individual characteristics.


The medication is excreted in the form of basic metabolites with urine and feces. In unchanged form, less than 5% of the daily dose is excreted, and in the urine, the drug in unchanged form is found only in small quantities. The plasma clearance is 8 ml / minute. The elimination half-life is about 20 hours.

Change in pharmacokinetics

The clearance of the drug in the elderly is markedly reduced. In renal / hepatic insufficiency (moderate severity), pharmacokinetics will not change significantly.

Indications for use

  • Ankylosing spondylitis;
  • rheumatoid arthritis;
  • osteoarthrosis;
  • acute osteoarthritis;
  • radiculitis with pain;
  • chronic polyarthritis;
  • other joint diseases of a degenerative and inflammatory nature.


  • ulcerative pathology of the digestive tract (Duodenum, stomach);
  • bronchial asthma ("aspirin");
  • age limit - up to 15 years;
  • pregnancy;
  • pronounced pathology of the renal system in the absence of regular hemodialysis;
  • feeding;
  • individual hypersensitivity.

Relative contraindications are erosive lesions of the digestive tract, elderly patient.

Side effects

Digestive tract

  • dry mouth
  • flatulence;
  • diarrheal syndrome;
  • nausea;
  • vomiting
  • epigastric pain;
  • stomatitis;
  • colitis;
  • hepatitis;
  • increase in ALT, AST, bilirubin;
  • gastrointestinal tract lesions of an erosive and ulcerative nature;
  • constipation;
  • bleeding from the gastrointestinal tract (explicit, hidden);
  • perforation of the intestines or stomach;
  • esophagitis.

Respiratory system

  • the appearance of cough;
  • exacerbation / worsening of the course of previously identified bronchial asthma.

The cardiovascular system

  • a feeling of rush of blood flow;
  • increase blood pressure;
  • heart rate increase (tachycardia).

Nervous system

  • confusion of thoughts;
  • dizziness;
  • headache;
  • disorientation;
  • noise in ears;
  • sleep disorders.

Urinary tract

  • proteinuria;
  • interstitial nephritis;
  • edematous syndrome;
  • renal failure;
  • hematuria;
  • infectious lesions of the urinary tract;
  • medullary renal necrosis.

Allergic answers

  • vasculitis;
  • anaphylactic shock;
  • Lyell's syndrome;
  • anaphylactoid reactions;
  • swelling of the tongue and lips;
  • exudative erythema;
  • fever.

Organs of vision

  • blurred visual perception;
  • conjunctivitis.

Dermatological reactions

  • hives;
  • skin rashes;
  • itchy skin;
  • increased photosensitivity.

Lem, instructions for use (Method and dosage)

Lem tablets are intended to be taken per os. To reduce the severity of negative reactions, it is preferable to take the medicine with food.

Rheumatoid arthritis

Manufacturer Recommended Daily Dosage meloxicama - 15 mg. The doctor may reduce the amount of medication to 7.5 mg / day, depending on the therapeutic effect of the drug.

Ankylosing Spondylitis

The daily dosage recommended by the manufacturer is 15 mg (cannot be increased).


Therapy begins with the appointment of 7.5 mg of Lemma per day. If necessary, the amount of meloxicam is doubled (in the absence of the expected effect).

Patients who suffer from pathology of the renal system and receive hemodialysis, as well as people with a predisposition to drug allergies, hypersensitivity are recommended to take no more than 7.5 mg of meloxicam per day. With a CC of more than 25 ml / min, correction of the treatment regimen is not required.


The clinical picture of poisoning consists of several negative symptoms:

  • bleeding from the digestive tract;
  • nausea;
  • impaired consciousness;
  • insufficiency of the hepatic system;
  • epigastric pain;
  • asystole;
  • respiratory arrest;
  • acute renal failure;
  • vomiting

Therapy includes procedures aimed at removing intoxication and removal of drug residues from the body: symptomatic and syndromic treatment, purpose Activated carbon and other enterosorbing drugs during the first hour after poisoning.

Timely application Colestyramine helps to remove the active substance of Lem from the body. The active ingredient Meloxicam binds poorly to plasma proteins, therefore, alkalization of urine, appointment forced diuresisand hemodialysis is ineffective. Specific antidote not developed.


The risk of developing ulcerative and erosive lesions (in the worst case, bleeding) in the digestive tract increases significantly with the simultaneous use of other drugs from the NSAID group.

Lem can reduce the effectiveness of antihypertensive drugs. The effect of cumulation of Li with simultaneous therapy lithium preparations (in the worst cases, a toxic effect is noted), which requires a mandatory measurement of the concentration of Li in the blood.

Methotrexate therapy may provoke leukopeniaAnemia, which requires control of the UAC. The risk of developing renal failure increases with the use of Cyclosporindiuretic agents.

Effectively reduced performance contraceptivesinstalled intrauterine.

The risk of bleeding increases with the appointment of thrombolytics (Fibrinolysin, Streptokinase), anticoagulants (Warfarin, Ticlopidine, Heparin), which requires control blood coagulation.

Colestyramine enhances the excretion of meloxicam from the lumen of the digestive tract, which is achieved due to the binding effect.

Terms of sale

Medication can be purchased at drugstores, kiosks. Presentation of a prescription form with a medical seal is required.

Storage conditions

Transportation and storage of tablets should be carried out in the original packaging, subject to temperature conditions (up to 25 degrees).

Shelf life

2 years.

Special instructions

For patients who receive anticoagulant therapy, Lem is prescribed with caution (increases the risk of bleeding from the digestive tract).

Persons with hypovolemia after surgery, as well as patients with cirrhotic lesion the hepatic system, with chronic heart failure, the drug is prescribed with caution under the control of the kidneys and blood counts.

Persons who use diuretics must take enough fluids during treatment. When registering allergic responses (urticaria, skin rashes, photosensitivity, pruritus), not stopping antihistamines (Tavegil, Tsetrin, Xizal) The lem is canceled.

Because the medication can cause headaches, drowsiness, dizziness, then during treatment it is not recommended to drive complex mechanisms / vehicles.

Analogs of Lem

Matches for ATX Level 4 code:MirloxRevmoxicamKsefokam RapidXefokamMovalisMesipolMelbekMovasinPiroxicamLornoxicamArthrosanTexamenAmelotexMeloxicam
  • Arthrosan;
  • Amelotex;
  • Melox;
  • Melbek
  • Bi-Xikam;
  • Meloxicam;
  • Mesipol;
  • Movasin;
  • Movalis.

For children

Lem can be used in pediatric practice after reaching the age of 15.

During pregnancy and lactation

Pregnancyis an absolute contraindication to the appointment of the drug Lem. Feeding It is recommended to stop while taking Meloxicam tablets.

Reviews about Lem

The drug has a pronounced anti-inflammatory effect, which allows it to be used in the treatment of most joint diseases. Patients note that Lem quickly enough allows you to stop pain syndrome, reduces swelling and redness in the affected joint, which increases range of motion and quality of life.

Of the negative reactions, an aggressive effect of the active component on the mucous membrane of the digestive tract is noted, which significantly limits the use of Meloxicam in patients with a history of gastric / duodenal ulcer.

With prolonged therapy, discomfort in the epigastric region appears, patients complain of dyspeptic disorders. The drug is effective in combination with drugs that help restore the structure of cartilage (Chondroitin, Glucosamine and others).

Price on Lem, where to buy

The cost of Lem depends on the region of sale, pharmacy, dosage of the active substance, the number of blisters with tablets in the package.

The average price of a medicine in Russia in a dose of 7.5 mg is 500 rubles per 30 tablets.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine

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Watch the video: Len - Steal My Sunshine (January 2020).

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