Active substances


Chemical name

Alpha-ethylbenzeneacetic acid 2-2- (diethylamino) ethoxyethyl ester (as citrate)

Chemical properties

A substance is a colorless liquid with a specific odor. Butamirate is poorly soluble in water, but good in alcohol, broadcast and acetone.

Usually in medicines butamirate citrate. Citrate is white, small crystals. The molecular weight of the compound = 499.5 g per mole. The tool has various lek. forms: syrup, tablets in or without film coating, coated tablets with modified release.

Pharmachologic effect

Bronchodilator, antitussive.

Pharmacodynamics and pharmacokinetics

The substance reduces the ability to be excited by the cough center in the brain, relieves irritation from the mucous membranes of the bronchi. Also, the product has a more moderate expectorant, bronchodilator and anti-inflammatory effect, increases the degree of saturation of blood with oxygen.

Butamyrate-based preparations have high absorption characteristics, are quickly absorbed from Gastrointestinal tract. In the body, a substance undergoes a reaction hydrolysis before 2-phenylbutyric acid and diethylaminoethoxyethanol. It is metabolites that have antitussive activity. Metabolites have a high degree of binding to plasma proteins.

After taking the syrup, the maximum concentration of metabolites is reached after 1.5 hours, after taking the tablets - after 8 hours. Withdrawal is carried out with urine. The half-life for syrup is about 6 hours, for tablets - 13 hours. The medicine does not accumulate in the body.

Indications for use

Prescribe a medicine for dry cough of any origin.

Used Butamirat for treatment whooping coughacute or chronic cough before surgery or in the postoperative period, during bronchoscopy. Various dosage forms of butamirate are used.


The substance is contraindicated in:

  • while breastfeeding;
  • at allergies;
  • in the first trimester of pregnancy.

Drops are usually prescribed for children under 2 months old, syrups - under the age of 3 years, tablet form - up to 6 years. Capsules and depot tablets are indicated at the age of 12 years.

Side effects

Rarely, butamirate preparations can cause the following side effects:

  • nausea, vomiting
  • allergies;
  • diarrhea and exanthema;
  • dizziness.

Most often, the medicine is well tolerated by patients.

Butamirate, instructions for use (Method and dosage)

The substance is prescribed orally, orally and rarely in / in, in / m.

Dosage, depending on age, is selected individually.

Syrup Butamirat take:

  • children from 1 to 3 years old - 15 ml per day, divided into 3 doses;
  • at the age of 3 to 6 years - 30 ml per day, the frequency of administration is the same;
  • children from 6 to 9 years old are prescribed 45 mg of the drug per day;
  • at the age of 9, you can take 15 ml of syrup, 4 times a day or 30 ml, 3 times a day (adults).

The tablet form is prescribed at the age of 6 years. Children from 6 to 12 - 5 mg, 2 times a day; children from 12 years old - 15 mg per day, for 3 doses; at the age of 18 years, you can take 20 mg of the drug, 3 times a day. Tablets are drunk before meals, not divided and not chewed.

Dragee, and prolonged-action dragees are taken in accordance with the instructions.

Before the operation, 20 drops of the drug are prescribed inside. For children, dosage adjustment is required.

Intravenous (20 mg) or intramuscular (50 mg) infusions of the substance may also be prescribed.


When an overdose occurs: nausea, diarrhea, drowsiness, lowering blood pressure, dizziness. As a treatment used laxatives (saline), give the victim enterosorbentseliminate unpleasant symptoms.


During treatment, it is not recommended to prescribe medications that depress the central nervous system (alcohol, antipsychotics, sleeping pills).

Terms of sale

The recipe is not needed.

Storage conditions

Storage conditions and shelf life of the drug depend on the dosage form.

Special instructions

Butamyrat preparations do not contain sucrosetherefore they can be taken sick diabetes.

If 4 days after the start of treatment with the drug without prior consultation with the doctor, improvement in the condition has not occurred, you need to seek help from a doctor.

It should be remembered that in the composition of 50 mg tablets is lactose.

During treatment with the drug, special care must be taken in patients with renal failure.

For children

Different dosage forms are used depending on age.

With alcohol

The drug is highly recommended not to be combined with alcohol.

During pregnancy and lactation

Butamirate should not be taken in the first trimester of pregnancy, the substance is excreted in breast milk.

Before starting treatment with a drug in the 2nd and 3rd trimesters, it is necessary to consult with your doctor.

Preparations that contain (Analogs)

Matches for ATX Level 4 code:OmnitusLibexinCodelac NeoSynecode

Analogs of Butamirat: Omnitus, Sinecode, Panatus, Brospamin, Sincodix, Stoptussin, Codelac Neo, Panatus Forte, Intussin, Butamirata Citrate, Codesin.

Reviews about Butamirat

Drug reviews are mostly positive. Adverse reactions are very rare. Judging by the reviews, syrup and drops based on Butamirate are more effective in combating cough. However, most likely, patients simply like “ease of use”, “pleasant taste and affordable price of syrup”.

It should also be noted that for greater effectiveness, it is better to take the medicine as prescribed by the doctor and follow its recommendations.

Butamirat price, where to buy

Syrup cost Codelac Neo is approximately 125 rubles per bottle, with a capacity of 100 ml.

Pills Omnitus can be purchased for 160-200 rubles, with a dosage of 20 mg, 10 pieces.

The price of drops for oral administration for children Synecode- about 360-400 rubles per bottle, 20 ml, dosage of 5 mg per 1 ml.

Watch the video: Бабамурад Хамдамов (December 2019).

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