Medication

Arthroker

Structure

In 1 capsule diacerein50 mg

Lactose monohydrate, croscarmellose sodium, magnesium stearate, sodium lauryl sulfate, povidone, silicon dioxide - as excipients.

Release form

Capsules 50 mg No. 30 or No. 100.

Pharmachologic effect

Anti-inflammatory, chondroprotective.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Diacerein(derivative anthraquinone) does not apply to non-steroidal anti-inflammatory drugs. It inhibits the synthesis of inflammatory mediators -interleukins 1, 6 and tumor necrosis factor TNF-α, which play a role in the inflammatory process, degradation and destruction of cartilage tissue.

Diacerein slows down the production of metal proteinases with which cartilage degeneration. With prolonged use stimulates the synthesis glycosaminoglycans, proteoglycansand hyaluronic acid.

Renders chondroprotectiveand anti-inflammatory effect reduces pain and when it is taken, the need for NSAIDs gradually decreases.

Pharmacokinetics

When taken orally, it is rapidly absorbed from the digestive tract. Deacetylation turns into rhein.

Eating increases bioavailability by approximately 25%. Cmax in the blood is determined after 2-3 hours. T1 / 2 - 255 min. 100% binding of rhein to albumin. With repeated use, Cmax rises, since cumulation of the drug is noted. Penetrates through the BBB and the placenta. It is excreted by the kidneys.

Indications for use

  • primary osteoarthrosis;
  • secondary osteoarthrosis.

Contraindications

  • hypersensitivity to anthraquinone(laxatives - senna, buckthorn, rhubarb);
  • intestinal obstruction;
  • intestinal inflammation;
  • pronounced hepaticorrenal failure;
  • lactose intolerance;
  • pregnancy;
  • lactation;
  • age up to 18 years;
  • lactase deficiency.

Caution should be used with a tendency to diarrheaand impaired renal function.

Side effects

Arthroker can cause:

  • rash, itching;
  • urticaria;
  • anaphylactic shock;
  • bronchospasm;
  • angioedema;
  • vomiting, nausea, abdominal pain, diarrhea.

In this case, the dose is reduced - 1 capsule per day.
Intensive staining of urine (to brown) does not require cancellation or reduction of the dose of the drug.

Instructions for use Arthrokera (Method and dosage)

Capsules are taken orally, whole, after a meal with a sufficient amount of liquid. The usual dosage is 1 capsule (50 mg) 2 times a day. The clinical effect is observed after 3-4 weeks. In the first 2 weeks of admission, loosening of the stool may be noted, in connection with which treatment is started with 1 capsule (50 mg) per day, and after 4 weeks the dose is increased to 2 capsules (100 mg). The drug can be taken continuously for a long time or in courses of at least 4 months.

Before the onset of the effect with severe pain, the drug can be taken with analgesic.

Instructions for use of Arthroker contain a warning that during treatment, monitoring of blood, urine and activity is necessary hepatic transaminases. When kidney function worsens, the dose of the drug decreases, or the question of its cancellation is decided.

Overdose

Overdose is manifested by symptoms: diarrhea, asthenic conditions. The treatment is symptomatic.

Interaction

It is not recommended to be taken simultaneously with laxatives or with foods that accelerate bowel movement (vegetables, fiber, joster). This can cause or exacerbate intestinal side effects.

When taking with antibioticsaffecting the intestinal microflora, or chemotherapeutic agentsalso increases the frequency of side effects from the intestines.

Antacidsbased aluminum and magnesium hydroxide decrease absorption and bioavailability diacerein.

Terms of sale

On prescription.

Storage conditions

At a temperature of no more than 25-30 ° C.

Shelf life

3 years.

Analogs of Artrocker

Matches for ATX Level 4 code:NimulideDiacereinAponilChondroitin sulfateShiganDonNimegesicArtiflexMovex ComfortNimesilNimicaArthron HondrexArthron FlexArthrodarinNemulexPiaskledin 300Chondroitin ComplexChondroitinGlucosamine HydrochlorideNutrilite Glucosamine

Diacerein, Diacerein Mac, Movagain, Diaflex Rompharm, Arthrodarin.

The price of analogues is practically the same. Capsules Diaflex Rompharm 50 mg No. 30 are offered at a price of 915-1288 rubles. Capsules Artrodarin (TRB Pharma S.A., Germany) in the same dosage and amount from 1799 to 2370 rubles.

Reviews about Artroker

Arthroker refers to symptomatic delayed-action drugs that are used for joint pain. They also include glycosamine sulfate, Chondroitin sulfate, hyaluronic acid preparations, Alflutop. Compared with NSAIDsthese drugs have a slower clinical effect, but it persists for a long time after treatment. Its action is aimed at slowing the progression osteoarthrosisstabilization of changes in hyaline cartilage. As you receive, the need for painkillers decreases and joint function improves.

Research has proven that effectiveness diacerinmore pronounced when hip osteoarthritis. The slowing down of the process of narrowing of the joint space after prolonged therapy with diacerein - 3 years has been demonstrated.

Reviews of Artrocker on the forums indicate this.

"I began to take Arthroker. I was treated intermittently, I noticed relief in a month and a half. At the very beginning of the reception my intestines hurt"

"I drank courses for 6 months. At the time of taking pain was not in the intervals between doses appeared, but were not as strong as before"

"Removes aching pain with osteoarthritis, I have the first stage"

"It helps me, all joints and spine hurt, I drink Artroker for the second month. After this drug, the pain decreased

"Everything normalized after taking the drug, and my hip joint hurt"

"I drink Arthroker 10 days. Side effects are not observed"

However, there are negative reviews that are associated with a slow development of the drug and the presence of adverse reactions in the form diarrhea. In this regard, there are very few patients who have been treated for many years. It must be borne in mind that effectiveness depends on the severity of the disease and the degree of impaired joint function.

Arthroker price, where to buy

You can buy in pharmacies in Moscow and other cities. The price of Arthroker in capsules of 50 mg No. 30 ranges from 730 rubles. up to 1205 rub. The cost of capsules No. 100 from 2300 rubles. up to 2980 rub.

  • Online Pharmacies in Russia

Pharmacy Dialog

  • Arthroker capsules 50mg No. 1002537 rub.order
  • Arthroker capsules 50mg No. 30864 rub.order
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