In 1 sachet - vitamin C and calcium gluconate0.2 g each paracetamol0.5 g, diphenhydramine and rutin, 0.02 g each

Polyvinylpyrrolidone low molecular weight, sugar, essence - as excipients.

Release form

Granules for dissolution, bag (sachet) 5 g.

Pharmachologic effect

Antipyretic, anti-inflammatory.

Pharmacodynamics and pharmacokinetics


What is pentaflucin from? This is a combined drug that has an antipyretic effect. The drug is prescribed to make you feel better with flu and the common cold, as it eliminates headache, nasal congestion, sore throat, and reduces cough.

Paracetamol- non-narcotic analgesic, has an antipyretic effect. Blocks COX1 and COX2v of the central nervous system.

Ascorbic acid is involved in blood coagulation, carbohydrate metabolism. Promotes tissue regeneration and increases resistance.

Diphenhydramine (diphenhydramine) has an antihistamine effect. Eliminates inflammation, swelling of the mucosa, has a sedative and hypnotic effect. Rutoside (routine) reduces capillary fragility, reduces blood coagulation, is an antioxidant. Calcium gluconate regulates calcium metabolism.


Paracetamol completely and quickly absorbed. Cmax is reached after 30-60 minutes. It is quickly distributed in tissues. It has low protein binding. Metabolized in the liver. Eight active metabolites conjugate to glutathione, in the absence of which metabolites block the enzyme systems of hepatocytes with the development of necrosis. It is excreted by the kidneys.

Cmax Rutosideachieved in 2-9 hours. T1 / 2 - 10-25 hours. Ascorbic acid is rapidly absorbed. Cmax 4 h. Metabolized in the liver.

Diphenhydramide(diphenhydramine) is also rapidly absorbed. Its bioavailability is 50%. Cmax after 20-40 minutes. The highest concentrations are found in the lungs, brain, kidneys, and liver. Penetrates through the BBB. It is excreted completely by the kidneys per day. A large amount is excreted in milk, which causes a sedative effect in infants.

Indications for use

Elevated temperature with colds and flu.


Pentaflucin is contraindicated in:

  • hypersensitivity;
  • renal/ liver failure;
  • tendency to hemorrhage;
  • of pregnancybreastfeeding;
  • under 16 years old.

With caution, the drug is prescribed for congenital hyperbilirubinemia.

Side effects

Pentaflucin may cause:

  • skin rash;
  • nausea, vomiting
  • drowsiness, headache;
  • dizziness, general weakness;
  • thrombocytopenia, agranulocytosisleukopenia (rarely).

When used in high doses, hepatotoxic and nephrotoxic effects are manifested.

Instructions for use Pentaflucin (method and dosage)

Take orally 1 sachet 3-4 times a day, preferably after a meal. Treatment lasts 3-5 days. Dissolve the contents of the bag in 0.5 cups of hot water, apply immediately. Slight sediment allowed.

Instructions for use Pentaflucin contains information that the drug should not be combined with alcohol. It is also necessary to refrain from driving vehicles.


Pentaflucin in case of an overdose can cause nausea, vomiting, and pain in the stomach. If the effect of the drug continues, after 2 days may occur encephalopathy, liver failure, coma.

Treatment consists in provoking vomiting, gastric lavage, the appointment of sorbents, and symptomatic therapy.


Pentaflucin enhances the action of drugs that reduce platelet aggregation and reduce blood coagulation.

Enhances side effects non-narcotic analgesics, NSAIDs, glucocorticoids, methotrexatederivatives sulfonylureas.

Combination with barbiturates, Diphenin, Carbamazepine, anticonvulsants, Rifampicin, Zidovudineand alcoholic drinks.

Terms of sale

Without recipe.

Storage conditions

At room temperature.

Shelf life

2 years.


Matches for ATX Level 4 code:AflubinCofexTeraFlu BroSuprima BronchoSinupretBronchostopDr. MomTonsilgon NTonsipretInstiImupretAntigrippin MaximumAntigrippin-ANVIAtmaViburkolTravisilRinicold BronchoUmkalorStodalAnviMax

Coldrex Max Flu, Coldflou, Antigrippinhave a similar effect.


The drug is used for symptomatic treatment with respiratory diseases. Everyone who took this drug notes its effectiveness, availability and low cost.

"Helps! Inexpensive and Effective"

"Good and fast helps with colds, quickly relieves the condition"

"Pentaflucin - an effective, effective and inexpensive tool"

"... an effective drug for the initial signs of a cold"

Of the disadvantages of the drug, its side effect is noted - drowsiness. This is understandable because it includes diphenhydramine. Pay attention to the fact that there is Pentaflucin daily (without diphenhydramine), devoid of this undesirable effect.

Pentaflucin price, where to buy

You can buy Moscow in many pharmacies. The price of Pentaflucin in granules of 5 g No. 10 sachets ranges from 109 rubles. up to 178 rub.

  • Online Pharmacies in Russia


  • Pentaflucin gran. 5g n10OAO Uralbiofarm172 rub.order

Pharmacy Dialog

  • Pentaflucin (teraflu) (por. 5g No. 10) 140 rubles to order
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