Medication

Cocarnit

Structure

In 1 ampoule nicotinamide20 mg cocarboxylases50 mg, cyanocobalamin 0.5 mg, adenosine triphosphate 10 mg.

Glycine, methyl parahydroxybenzoate, propyl parahydroxybenzoate - as excipients.

Release form

Lyophilisate for solution preparation + lidocaine solvent in ampoules.

Pharmachologic effect

Metabolic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

It is a complex of vitamins and substances that affect metabolism. According to the mechanism of action, it provides a neurometabolic, analgesic effect and affects the emotional-vegetative sphere.

Nicotinamidefavorably affects nitrogen and carbohydrate metabolism, participates in redox reactions and promotes the delivery of ATP to cells. It has a sedative effect, therefore it is effective in neuropsychiatric disorders, anxiety, depression, decreased attention.

Cocarboxylase- is a coenzyme that plays a large role in carbohydrate metabolism, improves trophism of tissues, affects synthesis nucleic acids, proteinand lipidspromotes assimilation glucose.

Cyanocobalaminpromotes the synthesis and accumulation of protein, activates the metabolism of fats and carbohydrates. The result of this action is a decrease in cholesteroland warning fatty hepatosis. Cyanocobalamin increases the regenerative ability of cells, necessary for the functioning of the blood-forming organs, nervous system and liver.

Adenosine triphosphate - derivative adenosineIt stimulates metabolic processes and is the main energy substrate of the cell. With ischemia, an energy deficit develops, which decreases due to adenosine triphosphate. Nicotinamide carries it into cells. Adenosine triphosphate has an antiarrhythmic, vasodilator and hypotensive effect.

Pharmacokinetics

Not studied.

Indications for use

  • neuralgiaof various origin;
  • neuritis;
  • lumbago, sciatica, radiculitis;
  • neuropathy(e.g. when diabetes);
  • myalgia, tendonitis, bursitis;
  • IHD, myocardiopathy, myocarditis;
  • during pregnancy is used if the benefit to the mother is greater than the risk to the fetus.

Contraindications

  • hypersensitivity;
  • erythrocytosis, erythremia;
  • severe form arterial hypertension and hypotension;
  • psoriasis;
  • conduction disturbances and severe heart failure;
  • myocardial infarction in the acute period.

With caution is prescribed when gastritis, peptic ulcer, goutlesions of the liver. Data on the use of children are not available.

In addition, contraindications for the solvent should be taken into account - 0.5% lidocainehydrochloride: sick sinus syndrome, Adams-Stokes syndrome and Wolf-Parkinson-White, angina pectoristension, epileptiform convulsions associated with lidocaine, myasthenia gravis, porphyriaheavy renal failure.

Side effects

  • headache, dizziness, weakness;
  • tachycardia;
  • skin rashes, itching;
  • anaphylactic shock;
  • hives;
  • sweating
  • diarrhea;
  • pulmonary edema;
  • thrombosisperipheral vessels.

Persons with hypersensitivity before the introduction of the drug spend an intradermal test.

Kokarnit injections, instructions for use (Method and dosage)

Intramuscularly administered 1-2 ampoules daily. Kokarnit injections are performed by courses, the duration of which depends on the severity of the disease.

The solution is used immediately after preparation, it should be red. If the color has not changed, it can not be applied.

The instruction on Kokarnit contains a warning about the need to carry out control platelet countand red blood cellscoagulation time bilirubin, uric acid and transaminase.

Overdose

If accidentally ingested, cocarnitis can cause toxicity, which is manifested by itching, flushing of the skin, headache, nausea, heartburn, and vomiting.

Chronic intoxication is expressed by an increase in the level of glucose, uric acid, and the appearance of duodenal ulcers.

Interaction

Cocarboxylase, which is part of the drug, enhances the cardiotonic effect cardiac glycosides.

Nicotinamide potentiates the anticonvulsant effect of antiepileptic drugs (Diazepam, CarbamazepineValproate).

Adenosine triphosphate with potassium-sparing diuretics, ACE inhibitors and potassium preparations increases the risk of developing hyperkalemia. Enhances the antianginal effect of β-blockers and nitrates.

When taking with Dipyridamoleincreased vasodilator effect.

Antagonism is shown when used in conjunction with caffeine and Theophylline.

Xanthinol nicotinatereduces the effect of adenosine triphosphate, and Carbamazepine enhances its effect.

Reduce cyanocobalamin absorption aminoglycosides, potassium preparations, salicylates, antiepileptic drugs and Colchicine.

Cyanocobalamin absorption is also reduced when taken Kanamycin, Neomacin, Polymyxin, Tetracycline.

Incompatible cyanocobalamin with ascorbic acid, Pyridoxine, Riboflavin, salts of heavy metals.

Oral contraceptives reduce the concentration of cyanocobalamin in the blood.

Terms of sale

On prescription.

Storage conditions

At a temperature of 15 to 25 ° C.

Shelf life

3 years.

Analogs of Cocarnith

Matches for ATX Level 4 code:Thiamine ChlorideCocarboxylase

Structural analogues with the same active substance are absent.

Reviews about Kokarnite

Reviews of doctors about Kokarnit injections for the most part indicate the effectiveness of the drug in neurological, neurosurgical and cardiac surgery.

In scientific studies of Belarusian scientists who used Kokarnit in cardiac surgery in the postoperative period, it was concluded that the drug significantly reduces the amount of wound discharge, vertebral pain, and the use of non-steroidal anti-inflammatory drugs.

Studies have shown that the condition myocardiumduring cardiopulmonary bypass during the operation, it was better in patients who took this drug in the preoperative period.

A number of studies have been conducted in patients with myofascial dysfunctionwho were prescribed this drug. On the 10th day of treatment, positive dynamics were observed: pain and muscle-tonic syndrome decreased. The vegetative-emotional sphere of patients improved: mood normalized, activity appeared, anxiety decreased.

The drug has proven itself in the complex treatment of patients with discogenic lumbosacral radiculitis. Cocarnit was administered intramuscularly at 2.0 ml per day for 14 to 21 days. The clinical effect occurred after 3 days. Regression of pain of the tonic syndrome was observed on 3-5 days. Side effects in patients were not noted.

Price Kokarnit where to buy

At the moment, it is not possible to purchase this drug in Moscow pharmacies, since it is not registered in Russia. In this regard, the price of Kokarnit is unknown. In online pharmacies, the drug is offered at a price of 113.55 rubles. for 3 bottles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Kokarnit lyoph. d / r v / m 187.125 mg n3 Egyptian International Pharmaceutical. Production Company618 rub.order

Pharmacy Dialog

  • Kokarnit (lyoph.d / r-v / m 187.125 amp.2ml №3 + r-l) 689 rubles to order

Eurofarm * 4% discount on the promotional code medside11

  • Kokarnit lyoph. d / in. 50 mg No. 3 amp. with solventEgyptian International Pharmacy820 rub.order
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Pharmacy24

  • Kokarnit 2 ml N3 solution for injection E.I.P.I.Ko., 20gipet205 UAH.order

Pani Pharmacy

  • Kokarnit pore. d / p r-d d / in.amp No. 3 Egypt, E.I.P.I.Co. 233 UAH to order
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BIOSPHERE

  • Kokarnit 2 ml No. 3 por.liof.d / r-ra d / in with r-lem E.I.P.I.K.produced for World Medical, United Kingdom (Egypt) 3 tg.
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