Medication

Mannitol

Structure

The composition of the solution includes the active component mannitol.

Additional components: sodium chloride, water for injection.

Release form

Mannitol is available as an infusion solution, packaged in 200 or 400 ml glass bottles.

Pharmachologic effect

The drug has a significant diuretic effect.

Pharmacodynamics and pharmacokinetics

Mannitol is osmotic diureticable to retain fluid in the renal tubules and increase urine volume, which is made possible by high pressure blood plasma and the filtration process occurring in the renal glomeruli without causing tubular reabsorption. The effect of the drug mainly extends to the proximal tubule. But to some extent affects the descending loop of the nephron and the collecting ducts.

The substance does not penetrate tissue or cell barriers, does not increase the concentration of residual nitrogen in the composition blood. With an increase in the osmolarity of blood plasma, fluid moves from some tissues to the vascular bed. Diuresis is accompanied by a moderate increase in natriuresis, without causing a significant effect on the excretion of potassium. The concentration, i.e. the dosage of the substance, affects the increase in the diuretic effect. The drug is not used for patients with impaired renal filtration function, azotemiafollowed by cirrhosis of the liver, ascites, as the volume of circulating blood may increase.

Determined that mannitol It has poor absorption from the digestive tract, so it is created in the form of a solution for intravenous administration. In the body, the distribution of the substance occurs in the extracellular sector with a concentration of about 3 hours. Low metabolism mannitol occurs in the liver, resulting in glycogen formation. The half-life is approximately 1.5 hours. From the body, the drug is excreted by the kidneys.

Indications for use

Mannitol is prescribed for:

  • brain edema, intracranial hypertensionaccompanied by renal or renal hepatic insufficiency;
  • oliguriawith acute renal or renal hepatic impairment, while maintaining the filtration ability of the kidneys - in complex therapy;
  • post-transfusion complications after poor blood compatibility;
  • forced diuresiscaused by poisoning barbituratesor salicylates;
  • prevention hemolysis during operations using extracorporeal circulation to prevent kidney ischemia and possible acute renal failure.

Contraindications

You should abandon the use of the drug with:

  • increased sensitivity to him;
  • anuriacaused by acute renal tubule necrosis;
  • left ventricular failure;
  • hemorrhagic stroke;
  • subarachnoid hemorrhage;
  • dehydration severe degree;
  • hyponatremia, hypochloremiaand hypokalemia.

With caution, the solution is prescribed to women with lactation and of pregnancy, elderly patients.

Side effects

When taking Mannitol, dehydration may develop, accompanied by dry skin and mouth, thirst, dyspepsiamuscle weakness spasms, hallucinations, lowering blood pressure. In addition, there may be a violation in the water-electrolyte metabolism, tachycardiapain behind the sternum, skin rash and thrombophlebitis.

Instructions for use Mannitol (Method and dosage)

As the instructions for use of Mannitol indicate, the solution is administered by drip or slow stream intravenously.

When conducting preventive measures, the dosage is calculated at 0.5 g per kg of patient weight. The therapeutic dose is 1.0-1.5 g per kg of weight and cannot be higher than 140-180 g.

Before administration, the solution is preheated to 37 ° C. If operations are performed with cardiopulmonary bypass, then the drug is introduced into the device at a dosage of 20-40 g before perfusion.

At oliguria pre-administered a test dose, intravenously drip. Then the patient's condition is controlled for about 2-3 hours. If the rate of diuresis does not increase to 30-50 ml / h, then the use of the drug is stopped.

Overdose

Cases of overdose are caused not only by the use of the drug in elevated doses, but also by its rapid administration. It may develop hypervolemia, rise intraocularor intracranial pressure, load on the heart and so on.

Interaction

The simultaneous use of the solution with other diuretic drugs can significantly enhance the mutual effect of each diuretic. The combination of the drug with Neomycin causes an increase in ototoxic or nephrotoxic effect. Mannitol may also increase the development of toxic effects when taken together with cardiac glycosides.

Special instructions

The presence of left ventricular failure requires a combination mannitol with high-speed loop diuretics, since the development of pulmonary edema is not excluded. In this case, you need to control blood pressure, diuresis and the concentration of potassium and sodium in the blood serum.

If drug administration causes headache, vomiting, dizziness, visual impairment, then the use of Mannitol is stopped in order to prevent the development of complications in the form of subdural and subarachnoid bleeding.

The appearance of symptoms of dehydration requires the introduction of additional fluid. Allowed for use in heart failure, in combination with "loop" diuretics, encephalopathy and hypertensive crisis.

Mannitol is reintroduced under close monitoring of the water-electrolyte balance of the blood composition.

Terms of sale

In pharmacies, Mannitol is prescribed.

Storage conditions

To store the solution requires a cool dark place inaccessible to children.

Shelf life

3 years.

Analogs

Matches for ATX Level 4 code:Mannitol

The main analogues: D-Mannitol, Mannitol.

Also have a similar effect: Furosemide, Trifas, Veroshpiron and Lasix.

Alcohol

The interaction of Mannitol with alcohol is not reported, but the indications for which this drug is prescribed suggest a rejection of alcohol.

Reviews about Mannit

As reviews about Mannitol show, it is often prescribed for the treatment of adult patients and in pediatrics. Moreover, many patients confirm its high efficiency. It is also reported that the drug is prescribed for treatment hydrocephalus in children, as a result of which pain is reduced and sleep is improved.

However, some users say that in addition to improvement, the use of Mannitol can cause side effects, for example: tachycardiapain behind the sternum.

If during treatment the development of unwanted symptoms occurs, then it is necessary to inform the doctor about this. After this, the drug can be canceled and replaced with another, more suitable medicine.

Mannit's price, where to buy

The price of Mannitol in a solution of 15% per 200 ml, in Russian pharmacies varies between 90-130 rubles.

  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

Pharmacy24

  • Mannitol 15% 200 ml solution for infusion 44 UAH
  • Mannitol 15% 200 ml solution for infusion 60 UAH

Pani Pharmacy

  • Mannitol infusion Mannit rr 15% 200ml Ukraine, Yuri-Farm LLC 58 UAH order
  • Mannitol infusion. Mannitr inf. 15% 200ml Ukraine, Novofarm-Biosynthesis LLC 51 UAH order
  • Mannitol infusion Mannitol solution inf. 15% 200ml Ukraine, Infusion CJSC 49 UAH order
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BIOSPHERE

  • Mannitol 15% 400 ml solution fl. Biochemist (Russia) 760 tg.
  • Mannitol 15% 200 ml solution fl.Infusion CJSC (Ukraine) 750 tg.order
  • Mannitol 15% 200 ml solution fl. Biochemist (Russia) 560 tg.
show more

Watch the video: Mannitol Diuretics Made Easy (January 2020).

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