Composed of tablets: 50 or 100 mg sumatriptan (sumatriptan succinate) + additional ingredients (microcrystalline cellulose, potato starch, magnesium stearate, hypromellose, macrogol, titanium dioxide, talc, lactose, sodium carboxymethyl starch, povidone, polyethylene glycol 4000).
The drug is released in the form of white or slightly grayish tablets of a round, biconvex form. If you divide the tablet in half, you can clearly see two layers. The inner one is white or yellowish, the outer one is the color of the shell. The medicine is produced in two dosages of 50 or 100 mg, in blister packs of 2 pieces each. In a cardboard pack two tablets of the drug.
Pharmacodynamics and pharmacokinetics
Sumatriptan constricts the vessels of the brain by interacting with 5-HT1 receptors in the brain. It is noteworthy that the substance does not affect 5-HT2 - 5-HT7 receptors. Serotonin 5-HT1D receptors also participate in the mechanism of action of the drug, however, in a selective manner. Thereby, trigeminal system not activated, but specific stimulating protein in the nuclei trigeminal nerve does not accumulate. Vessels that were dilated during a migraine attack, narrow, the attack stops. The drug does not have a direct analgesic effect.
When taken orally or intranasal the active component of the drug is rapidly absorbed into the systemic circulation. Its bioavailability is only 15%. After 2.5 hours, the drug reaches its maximum concentration of 51 ng per 1 ml. With the introduction intranasally this happens after 1.5 hours.
The drug has a low degree of binding to plasma proteins, about 17%, takes part in its biotransformations in the body MAO. Main metabolite sumatriptan - him glucuronide. The drug is excreted by the kidneys and through Gastrointestinal tract.
Improvements in the patient's condition begin to occur half an hour after taking 100 mg of the drug and 15 minutes after intranasal administration.
Within a day after an attack and taking the drug, relapse may occur, in connection with this, the drug is reused.
Indications for use
The drug is prescribed for the relief of attacks migraineoccurring with aura or without auras.
The medicine is contraindicated:
- pregnant and lactating women;
- at hemiplegic migraine;
- ophthalmoplegic migraine;
- basilar migraine;
- at stroke or other circulatory disorders of the brain;
- at ischemia;
- adolescents and the elderly;
- with serious liver diseases;
- at epilepsy;
- allergies on the components of the product;
- at transient ischemic attacks;
- when taking drugs that are not compatible with Amigrenin, for example MAO inhibitors, ergotamine (see lek. interaction).
Side effects from SS system: pressure reduction tachycardia and angina pectorispalpitations, increase blood pressure, bradycardia, ischemia. Very rarely possible Raynaud's syndrome.
Is possible allergy (hivesskin rash or itching).
Side effects from ZHTK: vomiting, indigestion, pain in the stomach, nausea. Rarely occurs ischemic colitis or level increase hepatic transmiasis.
By nervous system may manifest: weakness, drowsiness, impaired vision, apathy.
Also observed: sensations of heat, contraction, tingling or heaviness, muscle pain.
Instructions for Amigrenin (method and dosage)
The medicine can only be used for sudden attacks. migraineas an emergency remedy.
Instructions for use Amigrenin: The drug is prescribed for adults. The maximum amount per day is 300 mg. As a rule, 50 or 100 mg are prescribed at a time.
If after some time the symptoms have recurred, then the next dose can be taken no earlier than 2 hours, but no later than a day after the initial one.
If the drug did not bring relief, consult a doctor and take another medicine.
If an overdose of the drug occurs, symptomatic therapy should be performed. Wherein hemodialysis not an effective way to combat overdose. The doctor should monitor the patient for 10 hours after taking the drug.
A drug pharmacologically incompatible with MAO inhibitors.
The combination of funds with ergotamine may lead to prolonged spasm of blood vessels.
Simultaneous reception antidepressants and amigrenin increases the risk of hyperreflexia, impaired coordination of movements and asthenia.
The medicine increases toxicity furazolidone and lithium preparations.
It is highly recommended not to combine the drug with selegiline.
Terms of sale
In order to purchase the medicine, you need a prescription.
The drug is stored in a cool place protected from direct sunlight.
Particular care should be taken when prescribing the drug. epilepticsunder controlled arterial hypertension or people with reduced convulsive activity.
To avoid spasm coronary arteries in patients with diseases cardiovascular system, the first dose of the drug should be carried out under the supervision of a doctor.
With increased sensitivity to sulfonamidessevere allergic reactions are possible. Medication is not recommended.
Any pharmacokinetic features in patients older than 65 years were not revealed.
Due to the high risk of drowsiness when taking the drug, it is recommended to refrain from driving or performing activities that require a high concentration and reaction rate.
During pregnancy and lactation
The use of the drug during pregnancy and during breastfeeding is prohibited.
Analogs of AmigreninMatches for ATX Level 4 code:ZolmitriptanRapimedImmigrantZomigRelaxpackSumamigraineSumatriptan
Closest analogues: Sumitran, Imigran, Rapimed, Sumumik, Sumatriptan, Sumig, Trimigrain, Migrepam, Sumumigrain, Sumarin, Zomig.
There are many good reviews on Amigrenin on the forums on the Internet. The drug quickly helps and relieves painful migraine headache. Side effects sometimes occur, but patients still continue to take the drug, since, in their opinion, this is the only way to avoid attacks.
The price of Amigrenin is approximately 155 rubles for 2 tablets of 50 mg each.
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