Composition of Afobazole
Afobazole contains 5 or 10 mg of Afobazole as an active ingredient and auxiliary components:
- potato starch (Amylum solani);
- microcrystalline cellulose (Cellulose microcrystallic);
- milk sugar (Saccharum lactis);
- povidone (Povidonum);
- magnesium stearate (Magnesium stearate).
Afobazole is available in tablet form. The tablets are flat, cylindrical, with a bevel, packed in 10 or 25 pieces in blisters. Their color can vary from white to white with a cream tint.
Afobazole tablets can also be produced packaged in 30, 50 or 100 pieces in jars with a polymer cap.
Afobazol belongs to the pharmacotherapeutic group anxiolytic medicines.
Pharmacodynamics and pharmacokinetics
The active substance of the drug is a derivative of 2-mercaptobenzimidazole and is selective non-benzodiazepine tranquilizatoR (anxiolytic).
The drug does not have a stimulating effect on benzodiazepine receptorsbut has the ability to influence sigma-1 receptors of the brain, localized mainly in areas responsible for memory, emotions, sensory perception and fine motor skills.
Afobazole has a stabilizing effect on γ-aminobutyric acid receptor cell membraneswhile contributing to the restoration of their sensitivity to endogenous inhibition mediators.
In addition, Afobazole enhances bioenergy potential (BEP) nerve cells and, providing pronounced neuroprotective effectprotects them from damage.
The drug has a dual effect on the human body, which is expressed as a combination of sedative (anti-anxiety) and mild stimulating effects.
It reduces the severity (or completely eliminates) feelings of fear, somatic and autonomic manifestations of anxiety, emotional tension, increased irritability, relieves symptoms of post-traumatic stress disorders, symptoms of withdrawal symptoms, as well as other specific conditions.
Especially appropriate is the appointment of the drug to patients with severe asthenic features, which manifest themselves in the form of:
- increased vulnerability;
- mood variability;
- uncertainty, etc ...
The drug prevents the occurrence membrane-dependent changes in receptorswith sensitivity to GABA. Afobazole is not accompanied by hypnotic and muscle relaxant effects. Against the background of treatment, they did not observe a deterioration in memory function and impaired concentration of attention.
The patient's condition improves, as a rule, by the fifth or seventh day of treatment. The maximum effect is observed approximately three to four weeks after the first pill and is retained for another seven to fourteen days after discontinuation of the drug (depending on individual characteristics metabolism specific patient).
Afobazole is well absorbed from Gastrointestinal tract. The drug is characterized by a high degree of affinity for the cells of the human body and a high degree of binding to plasma proteins.
The drug is rapidly excreted from the body, which significantly reduces the likelihood of an overdose of it. The average half-life is about 50 minutes.
Indications for use of Afobazole
To understand why Afobazole is prescribed to the patient and why these tablets do not help, the pharmacodynamic characteristics of the drug should be taken into account.
In accordance with the annotation, indications for the use of this drug are:
- anxiety conditions including mental disordersaccompanied by a steady sense of anxiety that has no connection with specific objects or events, asthenic neurosisdisorders of adaptive reactions (adaptation disorders);
- anxiety disorders due to various dermatological, oncological, somatic (lupus erythematosus, hypertension, bronchial asthma, Ischemic heart disease, arrhythmia etc.) and other diseases;
- anxiety conditions noted with VSD (in combination with other activities, since drug therapy for vegetative-vascular dystonia only temporarily allows you to stop symptoms, but does not eliminate malfunctions nervous system);
- sleep disturbances resulting from increased anxiety;
- cardiopsychoneurosis (NDC);
- symptoms cyclic syndrome in women (PMS);
- alcohol withdrawal (alcohol withdrawal syndrome);
- withdrawal syndromearising from the rejection of cigarettes.
Contraindications to Afobazole
Contraindications to Afobazole are:
- hypersensitivity or intolerance to the active substance or any of the auxiliary components of the drug;
- galactosemia(galactose intolerance);
- monosaccharide intolerance (glucose-galactose malabsorption);
- lactase deficiency (lactase deficiency).
Also, the drug is contraindicated in children and adolescents who have not reached 18 years of agewomen during of pregnancy and women who breastfeed.
Side effects of Afobazole
Side effects of Afobazole are most often caused by individual intolerance to any of the components of the drug and are expressed in the form of various kinds allergic reactions:
- itching of the skin;
- angiitis etc.
Likelihood is not excluded nausea, vomiting and stool disorders. In rare cases, a side effect of taking Afobazole is headache, which does not require specific treatment, dosage changes or drug withdrawal and passes on its own.
Instructions for use Afobazole (method and dosage)
In accordance with the instructions for use, Afobazole tablets are intended for oral administration. Before you drink a pill, you need to eat.
A single dose of the drug is 10 mg. The recommended daily dosage of Afobazole is 30 mg. Tablets should be taken in three doses (that is, one 10 mg tablet or 2 5 mg tablets at a time).
Since the maximum therapeutic effect of taking the drug develops only at the beginning of the 4th week, the duration of the course of treatment is usually from 2 to 4 weeks.
Before taking Afobazole, a doctor’s consultation is required. This is due to the fact that certain conditions require an increase in the dose and duration of treatment. So, according to indications, the daily dose can be doubled, and the course of treatment extended to 3 months.
An overdose of Afobazole (meaning a significant excess of the therapeutic dose) provokes the development sedative effect and increased drowsiness, which is not accompanied by a decrease skeletal muscle tone and decreased motor activity.
When symptoms of intoxication Wikipedia recommends subcutaneous administration of 1 ml as an emergency caffeine sodium benzoate 20% injection. The drug should be pricked 2-3 times a day.
Afobazole has no effect on deprimative effect ethyl alcohol and hypnotic (hypnotic) effect Thiopental sodium (drug for inhalation anesthesia ultrashort action).
Potentiates antiepileptic effect Carbamazepine and enhances tranquilizing effect Diazepam.
Terms of sale
It is recommended to store the drug in its original packaging out of the reach of children at a temperature not exceeding 25 ° C.
It is suitable for use within 2 years from the date of manufacture. Use after the date indicated on the packaging is prohibited.
The drug does not affect the ability to drive a car and potentially dangerous mechanisms, so the answer to the question “Can I take Afobazole at the wheel?” Is positive.
It is also not forbidden to take the remedy for people employed in hazardous industries and people whose work requires attention and accuracy of reactions.
Analogs of AfobazoleMatches for ATX Level 4 code:SelankTranquesipamMebicarElsepamAdaptolAnvifenPhenibutFenazepamStresamNoofenTenothen
Like most other popular drugs, Afobazole has analogues, that is, drugs similar to it in their pharmacological action, but differing in composition.
The analogues of the drug are: homeopathic remedy Tenothen, Grandaxin, Stresam, Mebicar IC, Adaptol, Tranquilar IC.
The price of Afobazole analogues varies depending on the pharmacy and the manufacturer. Adaptol, for example, is slightly cheaper than Afobazole, but it is also effective, characterized by low toxicity, does not cause drowsiness, addiction and withdrawal syndrome.
Which is better - Tenoten or Afobazol?
Tenothen is a homeopathic medicine with antidepressant, antiastenic and anti-anxiety action. Acting on localized mainly in nerve tissue cells S-100 protein (a specific protein responsible for the regulation of intracellular processes), the drug normalizes its functional activity.
As a consequence of this, the body normalizes accordingly metabolic processes, as well as mechanisms of activation and inhibition CNS. Tenothen strengthens CNS, improves memory and concentration, and, in addition, increases the body's resistance to stress factors (including including hypoxia and intoxication).
Main advantage Tenoten before Afobazole is that it can be used both for the treatment of adult patients and for the treatment of children (the drug is allowed to be prescribed starting from the age of 3).
Another plus in favor Tenoten - this is what the drug can be used and how sedative, And How nootropic agent. Thanks to this combination of properties in one drug, it is possible to avoid taking several drugs at the same time and thereby significantly reduce the drug load on the patient's body and minimize the likelihood of side effects.
Novopassit or Afobazol - which is better?
NovoPassit is a sedative drug that is widely used to treat anxiety disorders and conditions accompanied by mental stress.
If Afobazole is a fully synthetic monocomponent drug, then Novopassit is a combination of extracts of seven different medicinal plants and guaifenesin.
In addition, unlike Afobazole Novopassit is having muscle relaxant and hypnotic effect.
Afobazole is tranquilizer, which improves behavioral functions, improves mood and energy of the body, reduces anxiety. Soothing effect, which provokes the use of the drug, while this is not the main, but secondary.
Novopassit belongs to the group sedative drugs. That is, it is already clear from the name of his pharmacotherapeutic group that he has a pronounced sedative effect.
Another difference between drugs is what to prescribe NovopassitPatients are allowed from the age of 12, and Afobazole - only to people who have reached the age of 18.
Given all of the above, it is difficult to give an unambiguous answer to the question of which of the drugs is better: they belong to different groups, have different indications for purpose, as well as different forms of release (so, Novopassitavailable in the form of tablets and syrup, while Afobazole is only tablets).
It is more correct to compare according to such characteristics as drug safety, patient adherence to therapy (compliance), ease of administration, effectiveness and price
Both drugs are considered safe, however, the likelihood allergies and intolerance reactions to reception Novopassita in individuals with weights allergic history and bronchial asthma, slightly higher than taking Afobazole.
Upon appointment Novopassita the likelihood of unforeseen drug interactions is also higher (since there are much more components in it than in Afobazole).
Assessing the compliance of drugs, we can say that it wins Novopassit. It contains only substances of plant origin, which is a big plus (especially for older people).
In terms of ease of use, competing drugs are about the same. The standard regimen for taking Afobazole tablets is one tablet three times a day. Novopassittake two or three tablets two to three times a day and another two or three tablets immediately before stress, which is not entirely and not always convenient. However precisely Novopassit has a liquid release form, which is more preferred for many patients.
If we compare the prices of drugs, then, of course, the Russian drug is much cheaper.
As for the effectiveness of the drugs, which, in fact, is the main evaluation criterion for most patients, it all depends on the individual characteristics of a particular organism, and no one will be able to accurately predict who will suit what more.
Which is better - Afobazole or Grandaxin?
And Afobazol, and Grandaxin used to treat the same ailments, relieve similar symptoms and are in about the same price category.
Testimonials of people who took according to indications Grandaxin indicate that:
- the effect of treatment with the drug develops very quickly, and a lasting effect is noted only a few days after the first dose;
- the drug effectively relieves symptoms of nervous tension;
- the taste of the tablets is neutral, and taking the product does not cause inconvenience or discomfort.
However, the reception Grandaxin often provokes nauseamany patients also noted some retardation and dizzinessthat were especially pronounced when changing position.
Reviews of Afobazole suggest that the latter:
- effective for anxiety conditions and helps to cope with unpleasant manifestations ICP;
- characterized as a low-toxic drug and has no pronounced side effects.
With strong stress the drug, however, is ineffective. It is also practically useless in the treatment insomnia, panic attacks and deep depression. That is, it is advisable to appoint it only in those cases when anxiety symptoms or stress are not pronounced. In difficult situations, more effective Grandaxin.
So the pros Grandaxin - this is its effectiveness in case of strong stress and severe anxiety, as well as the fact that even pregnant women (it is contraindicated only in the first trimester of pregnancy) Its minus is that the drug causes a greater number of adverse reactions than its competitor, Afobazole.
Which is better - Persen or Afobazole?
Comparison Persena and Afobazole incorrectly. This is due to the fact that the drugs have a completely different composition and different mechanism of action.
Persen is a completely herbal medicine that has a pronounced sedative effect, and is prescribed to patients suffering from insomnia and irritability.
The drug facilitates falling asleep and relieves excitability, but at the same time it has all the shortcomings and side effects that are inherent in its healing plants.
So, against the background of treatment Persen in some cases:
- sharply reduced blood pressure;
- addiction develops;
- the effectiveness of treatment decreases (sometimes even only a few days after the start of therapy);
- disturbed stool (in particular, constipation is frequent), etc.
Generally, Persen it’s quite difficult to name a drug: despite the fact that the drug is able to remove in a short time vasospasmprovide a relaxing and calming effect on CNS, he does not eliminate the cause of the symptoms.
Afobazole is tranquilizer point action, which is realized through a combination of anti-anxiety and stimulating effects. It can provoke a hypnotic effect only in those cases when the dose of its active substance exceeds at least 40 times the average effective dose (ED50).
After a course of taking Afobazole in patients, it is not only eliminated anxiety and disappears depression, but also significantly improved memory and attention.
Which is better - Afobazole or Adaptol?
Adaptol prescribed for the treatment of moderate pain in heartthat are not related to angina pectoris, to eliminate the constant craving for smoking, neurosisaccompanied by fears, anxiety, irritability and depressed.
It is also effective in the period menopauseat VSD and in conditions arising from the background oxidative stress. Adaptol renders easy anxiolytic effectnoticeably reducing fears and anxiety, and, in addition, has a positive effect on indicators functional activity of the brain.
After taking Adaptol partially bound to blood red blood cellsand partially with proteins, which allows it to spread rapidly in the patient’s body. Therefore, almost immediately after admission, the latter begins to feel peace and inner calm.
Act Adaptola not accompanied by a relaxation of skeletal muscles and a change in motor function. The tool does not have a hypnotic effect, but it has the ability to potentiate the effect of drugs prescribed for the treatment of sleep disorders (for which it can be prescribed simultaneously with these drugs).
Like Afobazole, the drug has extremely low toxicity. The drug is well tolerated by patients, available, does not cause tolerance and practically does not provoke side effects. For this reason, it is widely used in complex therapy in pediatric practice (Adaptol allowed for children from the age of 10 and this is its main difference from Afobazol).
Which is better - Phenibut or Afobazole?
Phenibut and Afobazole belong to the same pharmacotherapeutic group. Afobazole is characterized by the ability to have a pronounced anxiolytic effect, Phenibut is having tranquilizing and nootropic effect.
Both drugs are well tolerated by patients, but in some situations can provoke adverse reactions. So, after taking Phenibuta in some patients, drowsiness increases at the first doses. Afobazole intake may cause allergic reactions.
Unlike Afobazole, Phenibut can also be prescribed for children over 8 years old. The drug is often used in pediatrics for the prevention of motion sickness, treatment of ticks and stuttering.
Synonyms of Afobazole
Afobazole generics are: Afobazole GR, Neurophazole, Morpholinoethylthioethoxybenzimidazole.
Afobazole and alcohol
The instructions for the drug indicate that it does not affect the narcotic effect of alcohol (which is how it differs from others tranquilizersthat are not compatible with alcohol).
However, before using Afobazole with alcohol, you should weigh the pros and cons. After all, the drug is prescribed not just like that, but for stopping symptoms of neurosis and withdrawal syndrome, hormonal disorders in the female body, normalization of the function of internal organs.
Phenibut: alcohol compatibility for neurosis
Under neuroses understand various kinds mental disorderswhich are the consequence mental overloadand stress. Because alcohol inhibits activity CNS, Some people try to deal with these conditions with alcohol.
But if at first it partially gives a positive effect, then excessive drinking causes poisoning with toxins brain cells, which, in turn, enhances and exacerbates symptoms of neurosis.
This is especially evident in people with pronounced alcohol dependence. A patient suffering from chronic alcoholism changes his character and behavior, his aggressiveness increases, he becomes touchy and irritable.
Afobazole has the exact opposite effect: that is, it does not inhibit, but, on the contrary, stimulates activity CNSwhile eliminating signs of stress. Thus, combining the drug with alcohol, you can simply negate its positive effect.
The opinion that Afobazole can be used for treatment with alcohol is also erroneous. hormonal disorders among women. Alcohol toxic effect on gtin brain and in particular on hypothalamusresponsible for the coordinated functioning of the elements endocrine system organism.
That is, the simultaneous use of alcohol and Afobazole will only increase hormonal disorders. Moreover, somewhat dulled after drinking, the symptoms of hormonal disorders, as a rule, later return in an even more pronounced form.
Afobazole during pregnancy
Afobazole is prohibited when of pregnancy.
Since the active substance of the drug is characterized by the ability to penetrate the breast milk of a nursing woman, during the period of treatment with Afobazole, the issue of stopping lactation should be decided.
Reviews on Afobazole
Reviews about Afobazole on the forums are quite diverse. The main advantages are the effectiveness of the drug in anxiety and panic attacks, accessibility, relatively low price and almost complete absence of side effects (sedative tablets do not cause drowsiness, weakness and addiction). The effect of their use is already observed on the 4th-7th day of the course of treatment.
As a lack of reviews about Afobazole, it is indicated that the drug has contraindications (that is, it is not suitable for all groups of patients).
As for the reviews of doctors about Afobazole, they allow us to draw the following conclusion: the drug is effective, but only in conditions that are characterized as moderate. But with deep depression, he is unlikely to help.
The cost of Afobazole tablets depends on in which city and which pharmacy chain this drug is sold.
The price of Afobazole in Ukraine varies from 107 (in pharmacies of Lviv and Odessa) to 143 (in some pharmacies of Kiev) UAH.
To the query “How much do tablets cost in Russia”, search engines give prices from 272 to 394 rubles. You can buy tablets in online pharmacies on average at 299-313 rubles. The price of Afobazole in St. Petersburg is 301-320 rubles, in Moscow pharmacies - 310-347 rubles.
- Online Pharmacies in Russia
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- Afobazole 10 mg No. 60 tablets Pharmstandard-Leksredstva OAO (Russia) 2 tg.