Medication

Ginepriston

Structure

The composition of each tablet includes 0.01 g of the active substance - mifepristone. Also added excipients: 0.0746 g microcellulose0.0045 g sodium carboxymethyl starch and 0,0009 g calcium stearate.

Release form

It is available in the form of light yellow flat-cylindrical tablets, which weigh 0.01 g. Each tablet is placed separately or two tablets together in a blister strip or in a plastic jar. Each blister strip packaging or polymer can is in a pack of cardboard.

Pharmachologic effect

Possesses anti-gestagen action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Ginepriston is a synthetic steroidal antigestagen drug - it tends to block the action progesterone at the receptor level.

Its action stimulates an increase in contractility myometrium, promotes the release of substances that increase the sensitivity of the myometrium to certain types of hormones. Depending on what phase of the menstrual cycle the drug was taken, it can cause inhibition ovulationcontribute to change endometriumas well as discourage implantation an already fertilized egg.

Pharmacokinetics

Maximum concentration in the blood after taking a dose of 600 mg, a single dose is achieved after 1-1.5 hours.

Absolute bioavailability Ginepristone is equal to 69%.

98% of the drug received in the blood binds to plasma proteins, in particular albumin.

Excretion from the body is uneven. First, the concentration decreases by half slowly (up to 72 hours), then much faster. The half-life is 18 hours.

Indications for use

Ginepristone for interruption of pregnancy applied as postcoital (emergency) contraception, that is, in cases where the sexual intercourse was unprotected or if the method of contraception used with it was unreliable.

Contraindications

Contraindications include:

  • history of hypersensitivity to mifepristone;
  • adrenal insufficiency and long-term therapy glucocorticosteroids;
  • acute and chronic renal and / or liver failure;
  • severe form extragenital pathology.

Caution is advised when using Ginepristone when:

  • various violations hemostasis (including violations caused by previous treatment anticoagulants);
  • chronic obstructionWillow lung diseases (eg, bronchial asthma);
  • heavy arterial hypertension;
  • heart rhythm disturbances;
  • heart failure.

Side effects

A side effect of Ginepriston may be caused by a feeling of discomfort in the lower abdomen, weakness, headache, nausea, vomiting, dizziness, urticaria, hyperthermiaspotting from the genital tract may appear menstrual irregularities.

Instructions for use (Method and dosage)

Take 1 tablet inside no later than 72 hours after unprotected intercourse. Do not eat within 2 hours before and after taking the drug.

Ginepriston is used in any of the phases of the menstrual cycle.

Overdose

In cases of taking Ginepriston in doses not exceeding 2 g, undesirable reactions are unlikely. When taking a larger dose of the drug, adrenal gland function may be impaired, develop them failure.

Interaction

Concomitant use with non-steroidal anti-inflammatory drugs.

Terms of sale

Sold by prescription.

Storage conditions

Store in a dry, dark place. The ambient temperature must not exceed 30 ° C. The place where the tablets are stored should not be accessible to children.

Shelf life

3 years.

Special instructions

It is undesirable to use regularly, as a means of constant, planned contraception.

Analogs

Matches for ATX Level 4 code:MifepristoneMifeprexMitholianusGinestrilEsmiyaZhenaleMifeginMiropristonPencrofton

Analogs of Ginepriston are such drugs as: Ginestril, Mifepristone, Miropriston, Mifegin, Mifotab, Mtpill, Postinor, Escapel, Farmateks and some others.

Which is better: Postinor or Ginepriston?

Ginepriston acts on the woman’s body more gently than Postinor, and has a more convenient option - one tablet at once, and not two with an interval between doses of 12 hours. In addition, it is no less effective. Doctors recommend Ginepristone as a safer method.

Ginepriston or Escapel - which is better?

According to reviews of women who used these drugs, Ginepristone is often more effective than Escapel. Yes, and side effects are much less.

During pregnancy and lactation

Reception is contraindicated during of pregnancy.

Lactation must be stopped for two weeks if Ginepriston was taken.

Reviews about Ginepristone

There are already a lot of opinions about this drug as a means to abort pregnancy - these are the reviews of doctors and those people who used the drug.

Reviews of gynecologists about Ginepristone in most cases are positive, since it acts softer than most of these pills. Of course, this applies to those cases when the tablets are used according to the instructions for Ginepriston. But still, among the patients there are many complaints about the manifestations of side effects.

Ginepriston price, where to buy

The price of Ginepriston in a pharmacy is from 165 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine

ZdravCity

  • Ginepriston tab. 10mg n1Nizhfarm OJSC / OKHFK CJSC477 rub.order
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Pharmacy24

  • Ginepriston 10 mg No. 1 tablets ZAT "Obnіnska Hіm-Pharm.Kompanіya", Rosіya134 UAH to order

Pani Pharmacy

  • Ginepriston tablets Ginepriston tablet 10mg No. 1 Russia, Obninsk Chemical and Pharmaceutical Company CJSC 147 UAH order
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