Medication

Henferon Light

Structure

Structure suppositories for rectal or nasal administration:

1 candle (suppository) includes: recombinant human interferon alfa-2b - 250,000 IU or 125,000 IU (depending on dosage), taurine - 5.0 mg.

Excipients: macrogol 1500, polysorbate 80, citric acid, emulsifier T2, solid fat dextran 60,000, sodium hydrocytrate,purified water - the amount necessary to obtain a candle weighing 0.8 g.

Structure nasal spray:

One dose of the drug contains: interferon recombinant human alpha-2b - 50,000 ME, taurine - 1.0 mg.

Excipients: dextran 40,000, disodium edetate dihydrate, sodium chloride, potassium dihydrogen phosphate, potassium chloride, polysorbate 80, glycerol, methyl parahydroxybenzoate, sodium hydrogen phosphate dodecahydrate, peppermint oil, water for injection in the required amount.

Release form

For candles:

Candles of white or straw color. They have a cylindrical shape, a pointed end, they are uniform in the longitudinal section, but air inclusions are allowed. Available in cardboard packs, inside one such pack 1 or 2 contour packs containing 5 suppositories.

For nasal spray:

Light transparent liquid in bottles of darkened glass, equipped with a dispenser with a safety cap in the upper part; in a cardboard bundle one such bottle. 1 bottle contains 100 doses.

Pharmachologic effect

The pharmacological effect of the drug Genferon Light is due to the presence of alfa-2b and taurine in the composition of interferon. They have the following properties:

  • immunomodulatory effect (harmonization of the functions of immunity);
  • antiviral effect;
  • antiproliferative effect (inhibition of the multiplication of bacteria and cancer cells);
  • immunostimulating effect (improving the efficiency of the immune system);
  • indirect antimicrobial action;
  • anti-inflammatory effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The main active ingredient of Genferon Light is interferon alfa-2b. It is obtained by modifying bacteria Escherichia coli using genetic engineering.

Interferon is able to indirectly affect intracellular pathogens (chlamydia and viruses), changing the metabolism of the cell and stopping their intracellular replication and further spread. Interferon also affects neighboring cells, initiating reactions leading to inhibition of viral protein production. The effect of interferon on neighboring cells is an increase in the synthesis of substances that reduce protein synthesis. This mechanism is detrimental to the virus, because blocks its further reproduction. In addition, interferon activates a number of genes that play an important role in the antiviral defense of the cell and triggers the death mechanism of the infected cell.

Another direction of action of interferon is activation immunity. The result of this activation is a more effective fight of cells of the immune system (T-killers, phagocytes and T-helpers) with viruses and bacteria.

Taurine improves the metabolism of individual cells and tissues in general, stimulates reparative (restoration) processes. It improves and stabilizes the structure of cell membranes. Taurine is an antioxidant - interacting with active oxygen compounds in the body, it prevents tissue damage by these compounds.

Pharmacokinetics

For rectal use of the drug is characteristic bioavailabilityreaching 80% or more, which is associated with pronounced local and complex immunomodulatory effect. Vaginal administration is characterized by a pronounced local (a high concentration of the drug in the pathological focus is achieved) and a slight systemic effect (the drug practically does not penetrate the bloodstream through the mucous membranes of the internal genital organs). The result is a pronounced local antiviral, antiproliferative and antibacterial effects.

Interferon reaches its maximum concentration in the blood 4-6 hours after administration. It is excreted mainly by the kidneys. The elimination half-life is about 12 hours, the result of which is the need for a double preparation during the day.

Intranasal use is characterized by pronounced immunostimulating and antiviral effect (due to the large concentration in the pathological focus). The drug’s entry into the bloodstream during this route of administration does not reach large values ​​due to the special molecular structure of the membranes of the mucous membranes of the nasopharynx. However, a certain amount of interferon still enters the bloodstream, causing complex immunomodulatory effect.

Indications for use

Genferon Light in the form of candles is part of complex therapy and is used in the prevention of the following diseases in adults and children:

  • chlamydia
  • genital herpes;
  • mycoplasmosis;
  • ureaplasmosis;
  • gardnerellosis;
  • papillomavirus infection;
  • trichomoniasis;
  • cervical erosion;
  • vaginal candidiasis;
  • bacterial vaginosis;
  • vulvovaginitis;
  • cervicitis;
  • adnexitis;
  • urethritis;
  • bartholinitis;
  • balanitis;
  • prostatitis;
  • balanoposthitis;
  • ARVI;
  • flu.

Genferon Light in the form of a nasal spray is used for prevention and therapy. viral diseases of the respiratory tract.

Contraindications

Contraindications when using candles Genferon Light:

  • individual sensitivity to interferon or other substances in the composition of the drug;
  • the first 12 weeks of pregnancy;
  • epilepsy or other convulsive conditions;
  • severe cardiological conditions;

In patients suffering from autoimmune diseases (thyroiditis Hashimoto, systemic lupus erythematosus etc.) or allergic attacks In the past, Genferon Light candles have been used under close supervision and supervision.

Contraindications when using Genferon Light nasal spray:

  • individual sensitivity to interferon or other substances in the composition of the drug;
  • age up to 14 years.

With caution, the drug should be used in patients prone to nosebleeds.

Side effects

Usually, Genferon Light in the form of candles is well tolerated by patients. It may occur local (at the injection site) itching or burning. These symptoms disappear within three days after stopping the drug. To continue treatment, it is better to consult with your doctor.

Systemic reactions, such as fever, heatfatigue, loss of appetite, muscle, joint and headaches, as well as a decrease in the number of white blood cells and platelet countin blood. But these reactions are more common when exceeding the total administered dose of 10,000,000 IU per day.

When using the Genferon Light spray, no side effects were noticed.

Instructions for use

To exclude the possibility of an overdose or side effects on Genferon Light suppositories, the instruction requires children under 7 years of age to use only 125,000 IU suppositories. For children over 7 years of age, a dosage of 250 thousand IU is recommended. It is also worth noting that it is unacceptable to simultaneously use drops in the nose (for treatment catarrhal phenomena nasal cavity) and Genferon Light nasal spray, instructions for use warns of possible drug inefficiency in case of non-compliance with the rules for their separate administration. For the treatment of pregnant women with periods of 13-40 weeks, the use of candles with a dosage of 250,000 IU is recommended.

Recommended treatment regimens

  • ARVI, flu and other acute viral diseases in children: 1 suppository rectally every 12 hours as an adjunct to the main treatment for 5 days. If symptoms do not disappear, prolongation of treatment after a five-day break is possible.
  • Chronic viral diseases in children: 1 suppository rectally twice a day as an addition to the main treatment for 10 days. Then for 5-15 weeks - 1 candle every other day in the evening.
  • Sharp diseases of the genitourinary system infectious in children: 1 suppository rectally twice a day for 10 days.
  • Diseases of the genitourinary system of an infectious nature in pregnant women: 1 suppository rectally twice a day for 10 days.
  • Diseases of the genitourinary system of an infectious nature in women: 1 suppository of 250,000 IU twice a day for 10 days (vaginal or rectal). With a prolonged course of the disease, it is possible to use 1 suppository every other day in the evening for 5-15 weeks.

Genferon Light Spray is used by inserting the tip of the bottle into the nasal cavity and one short press on the dispenser.

When starting flu orARVI apply one dose in both nasal passages three times a day for 5 days (total daily dose should not be more than 500,000 IU).

For warning ARVI or flu (in contact with infected people) and after hypothermia, it is recommended to adhere to the following regimen of the drug: one dose in both nasal passages twice a day for 6-7 days.

Instructions for using the nasal spray.

  • remove the protective cap;
  • when using, press the dispenser for the first time repeatedly until a small jet appears;
  • before use, give the bottle a vertical position;
  • to administer the drug with a single short pressure on the dispenser in turn in both nasal passages;
  • close the protective cap after use.

To prevent the spread of infection, use the bottle strictly individually.

Overdose

With the simultaneous accidental administration of a large number of suppositories (in doses exceeding the prescribed), it is necessary to stop using the drug for one day, then you can resume treatment according to the prescribed schedule.

There are no data on cases of overdose with Genferon Light spray.

Interaction

Presence vitamins C and E enhance the effect of components of interferon and slow its denaturation with the introduction of the drug into the rectum.

Terms of sale

Genferon Light candles in Russia are sold by prescription, but the nasal spray can be bought without a prescription. In Ukraine, these drugs are sold strictly by prescription.

Storage conditions

The drug is advised to be stored out of the reach of children, dry and dark in a temperature range of 2-8 ° C.

Shelf life

Shelf life is 24 months. It is not recommended to use the drug after the expiration date (indicated on the package).

Special instructions

Genferon Light does not affect the reaction and the ability to perform actions that require increased attention (driving a car, equipment, etc.).

Analogs

Matches for ATX Level 4 code:Roferon AGenfaxonInferonLipoferonLifeferonIntron aBetaferonGrippferonIngaronAlfarekinLaferonPegintronPegasisInterlockInterferonNazoferonViferonInfagelReaferon LipintReaferon-EU-Lipint

Genferon Light's analog spray form is an Nazoferon.

Genferon Light's analogues shaped candles are Viferon Feron, Laferobion, Laferon Farmbiotek, Ruferon.

There are also analogues of the drug with other routes of administration: Alfarekin (injection) Virogel (ointment), Grippferon (nose drops) and others.

For children

It should be noted that the nasal spray is not recommended for use in children under 14 years of age.

Candles for children do not have age restrictions.

Newborn

The drug can be used as prescribed by a doctor in premature and newborn babies at a dosage of 125,000 IU if necessary (pneumonia, meningitis, sepsis).

With antibiotics

Share Genferon Light in the form of candles with antibacterial, antiviral and antifungaldrugs significantly increases the effectiveness of therapy.

Genferon Light during pregnancy

The use of Genferon Light "nasal spray" during pregnancy is possible at all times, and reviews on its use are generally encouraging.

The safety of the use of suppositories is proven only in pregnant women with a period of 13-40 weeks, while women in earlier pregnancy do not have data on the safety of use. In each clinical case, the question of the use of Genferon Light is decided separately by the attending physician.

Reviews on Genferon Light

Positive reviews about Genferon Light suppositories used during pregnancy were noted in the treatment of infectious diseases of the genitourinary tract. For both children and adults, it will be important to learn about the absence of reports of side effects.

Information on the practice of using the Genferon Light nasal spray for influenza and acute respiratory viral infections often also indicates its high effectiveness.

Price Genferon Light

In Russia, the price candles Genferon Light with a dosage of 250 thousand IU is approximately 245 rubles, with a dosage of 125 thousand IU - 180 rubles. In Ukraine, candles of 125,000 IU cost about 82 hryvnias, and for candles of 250,000 IU they will take 90 hryvnias.

Price spray Genferon Light in Russia it is approaching 250 rubles, in Ukraine it will be equal to 72-80 hryvnias.

  • Online Pharmacies in Russia

ZdravCity

  • Genferon light supp. vag / rekt 250tys.me + 5mg n10ZAO Biokad375 rub.order
  • Genferon light drops naz. 10 000me / ml + 0,8mg / ml (fl. + Nozzle-cap.) 10ml №1BJSC "Biocad" 311 rub.order
  • Genferon light supp. vag / rect 125tys.me + 5mg n10ZAO Biokad315 rub.order

Pharmacy Dialog

  • Genferon Light (suppositories vag. And rekt. 125000ME + 5mg No. 10294 rub. Order
  • Genferon Light Vaginal / Rectal Suppositories 25000ME + 5mg No. 10387 rub. Order

Eurofarm * 4% discount on the promotional code medside11

  • Genferon light drops 10 mlZJSC "Biokad" RU350 rub.order
  • Genferon light 125 000 IU n10 suppBiokad CJSC360 rub.order
  • Genferon light 250 000 IU n10 suppozJSC "BIOKAD" 430 rub.order
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