1 tablet of Nolicin contains 400 mg norfloxacin. Auxiliary components: magnesium stearate, microcrystalline cellulose, povidonepurified water, anhydrous colloidal silica.
The shell includes propylene glycolyellow dispersed dye E110, titanium dioxide, talc and hypromezole.
The medicine Nolitsin 400 mg is available in tablet form in blisters of 10, 20 pieces. Photos of the packaging can be seen at the beginning of the article.
Many people wonder: Nolitsin is antibiotic or not? The active substance has antimicrobial exposure in relation to staphylococci, klebsiel, enterobacteria, neiseria, Escherichia coli, chlamydia, legionella, salmonella, shigella and other pathogens of infectious diseases. The mechanism of action of the drug is based on the interaction of norfloxacin with DNA gyrase (an enzyme of the microorganism), which leads to the destabilization of the DNA chain, and the subsequent death of the microorganism. From this we can conclude that Nolicin is an antibiotic, as it has a detrimental effect on bacteria.
The antimicrobial effect can last up to 12 hours. The antibiotic Nolicin can be prescribed for diseases caused by mycobacteria, enterococci. Wikipedia contains a complete list of microorganisms sensitive to the action of an antibiotic.
Pharmacodynamics and pharmacokinetics
The active substance is quickly absorbed into digestive system, peak blood concentrations are recorded within 1-2 hours after taking the medication. The bioavailability of the drug reaches 30-40%. About 15% of the active substance binds to plasma proteins.
The drug is excreted through renal system unchanged, and only a small part is excreted through the digestive tract. In patients with severe renal system pathology, pharmacokinetic parameters are altered.
Indications for use of Nolitsin (Range of purpose)
Pills Nolitsin, what are they from? The drug is prescribed for the treatment of diseases of the genitourinary system of an infectious-inflammatory nature:
- chronic bacterial prostatitis;
- uncomplicated form of gonorrhea.
From what else can Nolitsin be prescribed: bacterial gastroenteritis, shigellosis, salmonellosis. Additional indications for the use of tablets: prevention of traveler's diarrhea and prevention of septic complications in patients with neutropenia.
Contraindications (absolute and relative)
An abstract to the drug contains the following absolute contraindications:
- fluoroquinolone intolerance;
- congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase.
The drug is not used in pediatrics.
- allergic responses to acetylsalicylic acid;
- epileptic syndrome;
- cerebrovascular disorders;
- atherosclerotic changes in the vessels of the brain;
Side Effects of Nolicin (Negative Effects)
From the genitourinary system:
- urethral bleeding;
From the digestive tract:
- pseudomembranous enterocolitis;
- epigastric pain;
- impaired appetite;
- diarrheal syndrome;
- bitterness in the mouth;
- increased ALT, AST.
Perhaps the development of hallucinations, headaches, arrhythmias, tachycardiavasculitis, pruritus, fainting, insomnia, swelling, urticaria, exudative erythema with a malignant course. Candidiasis, a decrease in hematocrit, changes in blood counts are rarely recorded, arthralgia, chemosis, fear of the world.
Instructions for use Nolitsin (Method and dosage)
How to use Nolitsin? Instructions for use recommend taking the medication inside.
At infectious lesions of the genitourinary system: 400 mg twice a day, course 7-10 days.
Treatment uncomplicated cystitis held within 3-7 days.
Chronically recurring urinary tract infectionstreated for 12 weeks.
How to take Nolicin with acute gastroenteritis of bacterial origin: 400 mg twice daily for 5 days. With cervicitis, proctitis, urethritis and pharyngitis, 400 mg of norfloxacin is prescribed once.
Manifested by intense vomiting, nausea, dizziness, drowsiness, "cold"later. Therapy includes hydration treatment with forced diuresis, gastric lavage. A specific antidote has not been developed.
Medication reduces effectiveness nitrofuransincreases concentration cyclosporine (mutual action) and indirect anticoagulants. Norfloxacin reduces the total clearance of theophylline by 1/4.
With simultaneous therapy with medications that lower the epileptic threshold, they may increase epileptiform seizures. Antacids reduce the absorption of Nolicin. When taking antihypertensive drugs, a sharp drop in blood pressure is recorded. The use of medications for general anesthesia requires mandatory monitoring of heart rate, blood pressure, heart function (ECG).
Terms of sale
It is released at the pharmacy with the obligatory presentation of the prescription medical form with the seal of the doctor and institution.
In a dark place, keep away from children. The temperature regime is up to 25 degrees Celsius.
Before prescribing an antibiotic, it is necessary to determine flora sensitivity to norfloxacin. Why is this being done? Pathogens may be sensitive to this drug, and the expected therapeutic effect will not be achieved at the right time.
At pyelonephritis Nolicin is recommended in combination with herbal medicines (e.g. Kanefron) In the treatment of norfloxacin, reviews with pyelonephritis are mostly positive. Monural also used to treat diseases of the genitourinary system. Only the attending physician can decide what is best prescribed.
Analogs of Nolitsin in RussiaMatches for ATX Level 4 code:SyfloxHailefloxLeflobactLefoccinGatifloxacinOfloxacinFactTigeronLebelZanocinLomefloxacinElefloxLomfloxPefloxacinTsiprobaySparfloTarividZofloxAbactalMoxifloxacin
Loxon-400, Sofazin, Norfacin, Norilet, Norbactin, Renor.
In pediatrics is not applicable. Age restrictions - from 18 years.
With alcohol (Adverse Reactions)
Alcohol and Nolitsin are not combined. Ethanol-containing drinks have a negative effect on the liver and the general condition of the patient.
In pregnancy (early and late)
Nolicin can be prescribed only for health reasons in the II and III trimesters. In the early stages, the medication is strictly contraindicated.
Reviews about Nolitsin (Opinion of doctors and patients)
Reviews on Nolicin with cystitis are extremely positive. The drug quickly stops all unpleasant symptoms of the disease (frequent urination, pain). Nolicin is an inexpensive and effective antibiotic for cystitis. Only the attending physician can prescribe a drug and explain how to take with cystitis. Reviews of doctors indicate that Nolicin is one of the drugs of choice in the treatment of diseases of the urinary system.
The price of Nolitsin in Ukraine, where to buy
The price of tablets depends on the package: 10 pcs - 90 UAH, 20 pcs - 195 UAH. You can buy Nolitsin in Russia at a price of 130 and 250 rubles, respectively. You can find out how much the medicine costs in your area by calling the pharmacy network.
- Online Pharmacies in Russia
- Online pharmacies in Kazakhstan
- Nolicin Tab. po 400mg n10Krka-Rus OOO 178 rub.order
- Nolicin Tab. po 400mg n20Krka-Rus OOO318 rub.order
- Nolitsin tablets 400mg №20355 rub.order
- Nolitsin tablets 400mg No. 10184 rub.order
Eurofarm * 4% discount on the promotional code medside11
- Nolitsin 0.4 №20OOO KRKA-RUS390 rub.order
- Nolitsin 400 mg No. 20 tablets of KPA KRKA (Slovenia) 1 tg.
- Nolitsin 400 mg No. 10 tab.po.KRKA (Slovenia) 780 tg.order